Hydrogels For Cell Derivation and Transplantation

Tech ID: 24120 / UC Case 2014-173-0

Patent Status

Country Type Number Dated Case
United States Of America Published Application 20190117782 04/25/2019 2014-173
 

Brief Description

The World Health Organization predicts that neurodegenerative diseases like Alzheimer’s and Parkinson’s will outpace cancer as the leading cause of death by 2040.  Currently these diseases can only be treated symptomatically, which does not slow or reverse the root cause of the disease.  Cell replacement treatments show significant promise as therapeutic treatments rather than palliative intervention. Unfortunately, less than five percent of transplanted cells survive engraftment. Additionally, those cells that do survive often differentiate into undesired cell types, leading to ineffective treatment or, worse still, to unregulated growth and tumorigenesis.

             

UC Berkeley researchers have developed a novel method to deliver therapeutic replacement neural cells to effectively treat neurodegenerative diseases, which not only increases the survival rate of replacement cells, but also serves to narrow their scope of differentiation into the desired cell types. The invention ensures replacement stem cells divide controllably and sustainably throughout treatment. 

 

Suggested uses

  • Cell delivery technology
  • Encapsulated neural cells may be transplanted into patients for treating neurodegenerative diseases, CNS diseases and potentially psychiatric disorders
  • Studying stem cell differentiation and development in a defined three-dimensional environment in vitro
  • Biomedical research 

Advantages

  • Significantly increases cell survival in transplanted cells 
  • Efficient derivation of desired neuronal cell type
  • Biocompatible, non-cytotoxic, non-immunogenic
  • Injectable for in situ transplantation
  • Reduce manufacturing burden in cell therapy applications
  • Reactions occur quickly in media, serum and in the presence of cells
  • Mild reaction conditions

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Inventors

  • Schaffer, David V.

Other Information

Keywords

Hydrogels, stem cells, therapeutic, neural cell, transplantation, neurodegenerative disorder

Categorized As