Systemic chemotherapy has been associated with damage to healthy tissue and in some cases induction of secondary malignancies. Transarterial chemo-embolization (TACE) is a commonly used procedure in hepatic malignancies designed to reduce the systemic dose. TACE therapy involves administration of chemotherapy directly to the liver via a catheter which is inserted through the femoral artery to the hepatic artery that directly feeds the hepatic tumor. The blood supply to the tumor is then embolized following chemotherapy to further increase the dose to the tumor tissue. Nonetheless, even with TACE up to 50% of administered doxorubicin (Dox) passes directly through hepatic tumors into the systemic circulation. To further increase tumor dose while reducing systemic exposure, UCSF scientists have developed a novel catheter incorporating a chemotherapy filter that is positioned transiently during TACE so as to bind Dox that has passed through the tumor before it enters the systemic circulation.
UCSF scientists have developed a specialized catheter device with filter that can be used in TACE procedures to bind Dox that enters the venous system and might then cause systemic damage. The device is guided to the desired vein via an internal jugular approach. Filters of adsorbent materials have been tested in an in-vitro model to bind and adsorb more than half of the Dox that is administered through the system. Prototype devices have been constructed and the feasibility of a novel intravenous chemotherapy filter device has been successfully demonstrated in-vitro with significant Dox binding in a physiologic TACE flow model. Binding performance has been characterized for various filter materials. Based on these results, physical-chemical properties of the materials are being optimized to develop even more efficient filters prior to in vivo device validation.
|Hong Kong||Issued Patent||HK1209018||09/20/2019||2010-112|
|China||Issued Patent||ZL 201380061710.9||06/15/2018||2010-112|
|United Kingdom||Issued Patent||2934376||06/06/2018||2010-112|
|United States Of America||Published Application||20150305850||10/29/2015||2010-112|