The generation of human induced Pluripotent Stem (iPS) cells holds great promise for development of stem cell therapies to treat a wide range of human diseases. However, the generation of iPS cells in the absence of integrative DNA vectors remains problematic. UCSD researchers have developed a simple, iPS generation approach to express reprogramming factors. Introduction of the vector into human fibroblasts results in the efficient generation of iPS cells with all the hallmarks of stem cells, including cell surface markers, global gene expression profiles and in vivo pluripotency to differentiate into all three germ layers.
|United States Of America||Issued Patent||10,370,646||08/06/2019||2012-374|
|United States Of America||Issued Patent||9,862,930||01/09/2018||2012-374|
|United States Of America||Published Application||19-0338252||11/07/2019||2012-374|