Researchers at UCLA have developed a novel vaccination strategy against tuberculosis in humans and animals. The invention also details the generation of a vaccine against leprosy and other mycobacterial diseases in humans and animals.
Tuberculosis (TB) infection remains highly prevalent worldwide. The WHO estimates 1.7 million deaths from TB annually. Africa and Southeast Asia have the highest burden of TB mortality. The persistence of TB infection has promoted the emergence of multi- and extensively drug-resistant (M/XDR) strains, which pose an imminent threat to industrialized nations. The vaccine currently used for TB, BCG, has been widely administered but lacks optimal protection. In fact, a large, carefully conducted meta-analysis by Colditz et al. (1994) estimates the potency of BCG protection to be approximately 50%. Therefore, new vaccines or booster strategies are necessary to combat TB infection. Improvements in the potency of TB vaccination will represent a significant advancement in global health and a step towards eradication of TB.
In an effort to improve the potency of BCG protection, researchers at UCLA developed a novel vaccine vector system for delivery of TB proteins. This system exploits a live, attenuated bacterial vector to deliver immunizing proteins. The novel booster vaccine can be administered after BCG or similar vaccination. In animal models, use of the novel vaccine induced greater protective immunity than either boosting with purified protein in adjuvant or boosting with recombinant viruses containing the same protein.
Vaccination for TB.
Researchers have genetically modified the bacterial vaccination vector to optimize the expression of immunoprotective proteins and eliminate any vector-mediated toxicity. In animal studies, administration of the novel booster vaccine induced lymphocyte proliferation and TB protection above BCG alone and above BCG plus a viral-based boost.
|United States Of America||Issued Patent||10,010,595||07/03/2018||2010-657|