Modular Aptazyme-Mediated Signal Transduction Coupled With Chemical Amplification In A Semi-Quantitative, Colorimetric Diagnostic Assay
Tech ID: 22151 / UC Case 2011-126-0
Researchers at the University of California, Berkeley, have invented an opto-biochemical amplification diagnostic platform, integrating novel biomolecular sensor and actuator components into high-throughput microfluidic systems. The system is composed of two parts: detection and amplified readout. Detection is achieved by using recently developed novel molecules as biomolecular sensors and actuators that are coupled to the second part of the system: a highly modular and versatile chemical amplification and colorimetric reporter scheme. This detection system could alternatively use antibodies.
This biochemical amplification and readout mechanism utilizes dynamic nanoplasmonic architectures to enable a visual color shift. This detection, amplification, and readout scheme will enable a new paradigm in low-cost molecular diagnostics.
- Facilitate point-of-test diagnosis for self-monitoring and patient testing in developed and developing regions of the world.
- Chemical amplification and colorimetric reporter system.
- Enables a visual readout with potentially a very low limit of detection.
- Simple to operate without the need for external equipment, power, or reagents.
- Highly modular and versatile low-cost molecular diagnostics.
- Revolutionize point-of-test diagnostics by enabling visual detection using biomolecular assays that have traditionally required the readout sensitivity of laboratory bench-top equipment.
- Allows for reagents to be stored and lyophilized on a microfluidic chip for long-term storage.