Modular Aptazyme-Mediated Signal Transduction Coupled With Chemical Amplification In A Semi-Quantitative, Colorimetric Diagnostic Assay

Tech ID: 22151 / UC Case 2011-126-0

Brief Description

Researchers at the University of California, Berkeley, have invented an opto-biochemical amplification diagnostic platform, integrating novel biomolecular sensor and actuator components into high-throughput microfluidic systems. The system is composed of two parts: detection and amplified readout. Detection is achieved by using recently developed novel molecules as biomolecular sensors and actuators that are coupled to the second part of the system: a highly modular and versatile chemical amplification and colorimetric reporter scheme. This detection system could alternatively use antibodies.
This biochemical amplification and readout mechanism utilizes dynamic nanoplasmonic architectures to enable a visual color shift. This detection, amplification, and readout scheme will enable a new paradigm in low-cost molecular diagnostics.

Suggested uses

  • Facilitate point-of-test diagnosis for self-monitoring and patient testing in developed and developing regions of the world.
  • Chemical amplification and colorimetric reporter system.


  • Enables a visual readout with potentially a very low limit of detection.
  • Simple to operate without the need for external equipment, power, or reagents.
  • Highly modular and versatile low-cost molecular diagnostics.
  • Revolutionize point-of-test diagnostics by enabling visual detection using biomolecular assays that have traditionally required the readout sensitivity of laboratory bench-top equipment.
  • Allows for reagents to be stored and lyophilized on a microfluidic chip for long-term storage.


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  • Dimov, Ivan
  • Henrikson, Richard
  • Lee, Eric
  • Lee, Luke P.
  • Mitra, Debkishore
  • Waldeisen, John R.
  • Yeh, Erh-Chia

Other Information

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