The β-lactam ring is essential for antibiotic function within the broad class of β-lactam antibiotics, which is divided into subclasses based on additional structural elements. One subclass in particular, the carbapenems, is produced by chemical synthesis rather than by fermentation. Since the carbapenems have shown themselves to be an important basic structure for active antibiotics, a great deal of effort, using synthetic organic chemistry, has been put toward the production of the key structural elements involved in the active pharmaceutical agents.
Researchers at UC Santa Cruz have developed a novel approach to the production of β-lactam compounds by decomposition of an α-diazo-β-ketoamide without the use of metal or chemical catalysts, and without the use of a mercury vapor lamp, which causes metal contamination. Instead, with the use of a fluorescent light source, and using an inexpensive and enantiomerically pure (α-amino acid) starting material, this procedure is ideal for the synthesis of β-lactam antibiotics.
|United States Of America||Issued Patent||8,946,408||02/03/2015||2009-564|
Beta-lactam, antibiotics, carbapenems, synthetic production, pharmaceutical, Cat1