pH-Responsive Nanovalves for On-Demand Release of Guest Molecules
Tech ID: 21559 / UC Case 2008-374-0
UCLA inventors have developed novel nanovalves that aid in the release of guest molecules, such as anticancer drugs, in response to pH levels.
Neuropathic pain is a type of chronic pain caused by the dysfunction of one or more nerves. This type of pain represents a challenge in medicine because of its frequency, severity, and limited number of effective treatment options. In the USA and European countries, the prevalence of neuropathic pain is between 1.5 and 7.7% of the population. Most patients respond poorly to standard pain therapies involving pain killers. One treatment that has been used to reduce neuropathic pain is antidepressants. Antidepressants are useful, however the mechanisms are unknown and they have unwanted side effects. Therefore, there is a need to uncover how antidepressants work in neuropathic pain, which would then open up new targets to design better analgesics.
Researchers at UCLA have invented a novel pH-responsive nanovalve system that employs biocampatible components, relies on ion-dipole interactions, and operates in aqueous media. This was achieved by filling a tiny, porous silica sphere with a drug and then plugging the pores with the valves. Applying this system, researchers can use pH changes to control a drug's release. Current nanovalves can open in locations where low pH conditions occur, such as in the lysosome of a cell, or in the acidic environment of the stomach.
- On-demand release of anticancer drug in cancer therapy
- On-demand release of anti-microbial drugs in dental treatment
- On-demand release of anti-viral drugs in agriculture
- Operates in aqueous media (physiological condition)
- Responds to low pH
- Consists of pseudorotaxane molecules
State Of Development
The invention has been validated in aqueous solutions.
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- Thoi D. Nguyen, Ken C.-F. Leung, Monty Liong, Cari D. Pentecost, J. Fraser Stoddart, and Jeffrey I. Zink; Construction of a pH-Driven Supramolecular Nanovalve Org. Lett., 2006, 8 (15), pp 3363-3366
- Sarah Angelos, Ying-Wei Yang, Kaushik Patel, J. Fraser Stoddart,* and Jeffrey I. Zink* "pH-Responsive Supramolecular Nanovalves Based on Cucurbit uril Pseudorotaxanes Angewandte Chemie" Volume 120, Issue 12, Article first published online: 14 FEB 2008]
- "Nanovalve for Drug Delivery". by Jocelyn Rice. Technology Review. March 13, 2008
- "US team claims a first in nanovalves for drug delivery". in-Parma Technologist.com. March 19, 2008.
- "Nano Targeted Drug Delivery". by Asaf Peer. The Future of Things. July 14, 2008