Researchers at the University of California, Irvine have developed a CD microfluidic device that is capable of blood plasma separation of 2 mL of undiluted blood samples. A technician would pipette into the CD device the blood sample for separation. The device is then rotated at high frequencies in order to separate the plasma from the blood. As the frequency of rotation for the CD device is decreased, a siphon valve is primed due to the low frequency of rotation; and the plasma is separated into a collection chamber.
This device may be used in the clinic with patients and in research labs for research applications.
Currently, a clinical technician is required to prepare blood samples for centrifugation. The current process takes more than 20 minutes. By using the UCI microfluidic device, the preparation and separation of blood plasma can take less than 5 minutes. Since this device is automated, there is less human error and samples may be multiplexed.
A prototype has been developed and blood plasma has been successfully shown to be separated with this device.
|United States Of America||Issued Patent||9,186,672||11/17/2015||2011-429|