Prevention And Treatment Of Chlamydia Trachomatis Infection Using A Protective Antibody

Tech ID: 20502 / UC Case 2005-555-0

Background

Urigenital infection with Chlamydia trachomatis is a major sexually transmitted disease, a cause of infertility and one cause of pelvic inflammatory disease. Infection in the eye by the bacterium (trachoma) is also the leading worldwide cause of blindness. Chlamydia infections are treated with antibiotics, but these are effective in only about half of all cases, and even less for chronic infections. No effective vaccine against the pathogen has been developed, nor is there one on the horizon.

Innovation

UCLA researchers have developed a new approach to prevent and treat infection by Chlamydia trachomatis. The scientists developed an antibody against a host protein that the pathogen uses to infect a cell. Experiments in vitro demonstrate that blocking the protein with the antibody greatly impedes infection. In vivo studies are currently being performed. The novelty of this invention lays in the identification of a host protein that is required for Chlamydia trachomatis infection. Current therapies target the pathogen itself. Thus using this antibody to block infection could lead to the first prophylaxis for Chlamydia, and possibly a new class of therapeutics as well.

Applications

  • A topically applied formula containing the antibody or peptide antigen could be developed to prevent and/or treat Chlamydia trachomatis infections. For example, an intravaginal or condom-coating ointment similar to a spermicide could be developed.
  • Additionally, eye drops containing the antibody could be developed for the prevention and/or treatment of trachoma.

Advantages

  • This is the first host-based molecule discovered to be involved in the entry of Chlamydia trachomatis.
  • This invention allows for the development of preventative therapies; current therapies for Chlamydia treat active infections.

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 9,624,304 04/18/2017 2005-555
United States Of America Issued Patent 9,011,857 04/21/2015 2005-555
United States Of America Issued Patent 8,785,602 07/22/2014 2005-555
United States Of America Issued Patent 8,779,104 07/15/2014 2005-555
United States Of America Issued Patent 8,648,052 02/11/2014 2005-555
United States Of America Issued Patent 8,318,906 11/27/2012 2005-555
 

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Inventors

  • Braun, Jonathan

Other Information

Keywords

therapuetics

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