UCLA investigators have developed novel positron emission tomography (PET) probes to image and monitor immune activation and selected cancers. One of these PET probes has been successfully synthesized and tested in mice.
Positron emission tomography (PET) is a medical imaging technique that scans the body, producing a three-dimensional image or map of the bodys biological processes. In order to conduct the PET scan, subjects receive an intravenous injection of a minute amount of a metabolically active molecule labeled with a radioisotope that will image the biological process of interest. Current existing PET-probes, such as FDG, do not have the specificity to image immune activation responses. There is a need for novel PET probes that are sensitive and specific for the monitoring of immune activation.
Researchers at UCLA have developed novel positron emission tomography (PET) probes to image and monitor immune activation. Various chemical compounds were screened to identify ones that accumulate in activated lymphocytes, and then labeled with the positron-emitting radioisotope F-18 to generate PET probes. These PET probes specifically target proteins expressed during activation of T lymphocytes and of other immune cells such as B cells, macrophages and dendritic cells. In vivo imaging of activated immune cells was then demonstrated.
UCLA researchers have identified target genes that are upregulated during T cell activation and are using proteins expressed from these genes to design chemical structures for PET probes. Investigators have been successful in synthesizing one of the PET probes and testing it in mice that underwent systemic immune activation. Investigators also tested this probe for imaging certain hematologic malignancies and solid tumors.
|United States Of America||Issued Patent||8,101,740||01/24/2012||2007-475|