Neuronal Outgrowth Modulated by MHC molecules

Tech ID: 20068 / UC Case 2000-118-0

Summary

UCLA researchers have developed new major histocompatibility complex class I (MHCI)-based treatments to modulate neuronal outgrowth that may be used to promote neurorepair and inhibit neurodegeneration.

Background

Major histocompatibility complex (MHC) molecules are cell surface molecules that are key players in the immune system and have been mostly studied in the context of immune system cells, or leukocytes. More recently, MHCI has been found to play a critical role in modulating neuronal synaptogenesis and outgrowth. 

Innovation

Researchers at UCLA discovered that recombinant soluble MHCI/peptide proteins acted as “stop signals” for neuronal outgrowth. Conversely, over-expression of MHC heavy chain in neurons promoted neurite outgrowth, suggesting that heavy chain cis interactions with other neuronal molecules can promote neuritogenesis while MHCI/peptide interactions with MHCI receptors can inhibit axon outgrowth. Therefore, blocking MHCI/peptide interactions with their receptors, or enhancing MHCI heavy chain expression, are promising candidates for promoting neurorepair or inhibiting neurodegenerative diseases. 

Applications

Agents that limit MHCI/peptide interaction with its receptors, or agents that promote MHCI heavy chain expression, as therapeutics for neurorepair and neural degenerative diseases may be developed.

State Of Development

• Enhanced expression of MHCI heavy chain in cultured neurons led to faster neurite outgrowth and more primary neurites.
• Transgenic mice with enhanced MHCI heavy chain expression had significantly better recovery of locomotor abilities after spinal cord injury than wild-type mice.
• Neurons naturally shed soluble MHCI/peptide molecules that inhibit neurite outgrowth, but this could be prevented by addition of anti-MHCI antibodies.

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 7,553,484 06/30/2009 2000-118
 

Contact

Learn About UC TechAlerts - Save Searches and receive new technology matches

Inventors

  • Kaufman, Daniel L.

Other Information

Keywords

Major histocompatibility complex (MHC), neuro-degenerative, degenerative, neurorepair, brain injury, central nervous system (CNS), synaptogenesis, Alzheimers disease, Parkinsons disease, spinal cord injury, retina, ganglion, perforant path lesion model, lateral geniculate nucleus, neuron, synaptic plasticity, neural activity

Categorized As

Additional Technologies by these Inventors