Combinatorial Transcription Control

Tech ID: 19732 / UC Case 2003-087-0

Technology Description

UC San Diego inventors have developed strategies and methods for exertion of combinatorial control on gene expression by integrating multiple transcription signals directly in the regulatory region without the need for additional genes and their expressions. (See White Paper PDF below for additional details.)


The potential of programming genetic responses “at will” using this approach offers a multitude of applications in bioengineering, biomedicine, molecular agriculture, and other fields that benefit from manipulation of gene expression. For instance, it can be designed to detect specific gene expression patterns associated with hazardous, defective, degenerative, enhancing, or regenerative factors in organisms ranging from bacteria to humans, and thereby allowing the targeted expression of genes for reporting or therapeutic purposes.

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 8,301,387 10/30/2012 2003-087


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Other Information


genetic control, detection of disease

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