New Anti-Microbial and Anti-Biofilm Silicone Formulation

Tech ID: 18707 / UC Case 2009-147-0

Technology Description

Scientists and physicians at the University of California, Irvine have developed a new silicone formulation that appears to be resistant to encrustation and biofilm formation during in vitro testing. Further in vivo studies are in progress.

Applications

The new silicone formulation may be useful for urinary tract stents, catheters, and nephrostomy tubes. In addition, it may possibly be of value in the development of a prosthetic bladder material for partial or eventually even total replacement of the bladder.

Background

Recurrent blockage of urinary catheters and indwelling ureteral stents made of silicone and other materials is a common problem. Blockage is frequently caused by the build-up of precipitated mineral deposits (i.e. encrustations) on the catheter or stent surface. In addition, various bacteria in the urine can adhere to the surface and create a protective biofilm thereby precluding effective antibiotic therapy and further contributing to mineral deposition.

The problem of biofilm and encrustation has been approached by developing anti-microbial coatings or the inclusion of organic anti-microbial components into the substance of the stent itself. However none of these anti-microbial techniques is completely effective.

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 8,257,827 09/04/2012 2009-147
 

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Other Information

Keywords

silicon, urinary catheter

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