Researchers at the University of California, Davis and Lawrence Livermore National Laboratory have developed a non-invasive method of applying single-cell Raman spectroscopy to the early detection of cancer cells.
Early detection of cancer is key to effective treatment and increased survival rates. Current methods of malignant cell identification include chemical stains, labeling and light microscopy. However, each of these techniques is cumbersome or invasive (sometimes both). Another limitation to current diagnostic approaches is that they can be limited to analyzing only bulk samples of cells.
Researchers at the University of California, Davis and Lawrence Livermore National Laboratory have developed a method of Raman spectroscopy that uses laser tweezers to optically trap individual cells in solution. This technique allows for the non-destructive, non-invasive analysis of cells and subcellular components. Raman spectroscopy of a single, non-affixed, cell can yield a defining, bio-molecular, fingerprint of either a cell or a subcellular component - without altering its biology. Furthermore, combined with a specific method of isolating cells, the invention can analyze either different areas of the same cell or different cells within the same cell sub-population simultaneously.
|United States Of America||Issued Patent||10,365,220||07/30/2019||2004-500|