Professor Iman Noshadi and colleagues from the University of California, Riverside have developed an innovative, transparent, and highly effective material called BioPEG hydrogel for corneal repair. This technology is a next-generation anti-microbial bioadhesive that leverages a flexible polymer (PEGDA) to provide a scaffold that is supple enough to conform to the delicate surface of the eye and facilitate corneal repair and regeneration. This technology is advantageous because the antimicrobial hydrogel is applied as a liquid and rapidly cures using visible light to form a strong, watertight, and highly adhesive transparent patch.    Fig 1: A schematic of the UCR BioPEG synthesis: visible light crosslinks the hydrogel structure from polyethylene glycol diacrylate (PEGDA) and bio-ionic liquid. 

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Professor Linlin Zhao and their team from the University of California, Riverside have developed mTAP, a new chemical probe engineered to selectively bind to abasic sites within mitochondrial DNA without affecting nuclear DNA. Unlike non-specific agents, mTAP is equipped with a mitochondria-targeting group, ensuring its precise localization. This invention is advantageous over current technology because its mechanism of action involves forming a stable chemical bond with damaged DNA sites, thereby protecting mtDNA from enzymatic cleavage and maintaining its replication and transcriptional activities.    Fig 1: The UCR mitochondria-targeting water-soluble probe mTAP exclusively reacts with mitochondrial abasic sites, and retains mitochondrial DNA levels under genotoxic stress which are responsible for certain mitochondrial diseases. 

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Professor Anubhuti Goel and colleagues from the University of California, Riverside have developed a novel diagnostic tool and software program that provides a quick, objective measure of sensory issues for individuals with Autism spectrum disorders and Fragile X syndrome. This tool works by using a software application to administer a game. Based on the individual’s score at the end of the game, a diagnosis about sensory issues may be made. This technology is advantageous because it may provide an easily accessible, low cost, and safe diagnostic tool for Fragile X Syndrome and Autism that can be developed as a telehealth diagnostic tool.     

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This invention provides a data-driven method to time-synchronize waveform data from conventional power quality meters. The algorithm transforms non-synchronized measurements into synchro-waveforms. This is achieved without needed expensive hardware upgrades. The method first aligns event signatures from different meters and then calculates a synchronization operator to align the entire dataset. The process unlocks the potential of advanced monitoring and analysis of existing grid infrastructure.

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Dr. René Riedel and Stephen Lepore from the University of California, Riverside have developed an NMR tube/reactor that enables in-situ irradiation to photo-initiate reactions in an inert or controlled atmosphere. It allows for the data acquisition of air, moisture, and temperature-sensitive liquid samples by nuclear magnetic resonance (NMR) spectroscopy without needing to remove the sample from the spectrometer for irradiation. This technology is advantageous because it makes photochemical reactions and kinetic measurements of sensitive samples more reproducible, and it enables the previously impossible maintenance of a controlled environment during photochemical NMR investigations.

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Professor Hideaki Tsutsui and colleagues from the University of California, Riverside have developed a portable handheld device for nucleic acid extraction. With its high-speed motor, knurled lysis chamber for rapid sample lysis, and quick nucleic acid extraction using paper disks, this device can yield ready-to-use extracts in just 12 minutes, significantly reducing the time required for sample preparation. This technology is advantageous over current methods as it can be expedited without the need for cumbersome specimen collection, packaging, and submission, shortening the turnaround time.  

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The University of California, Riverside has developed a new omics software named, ShowMEPATH, employing a faster and easier approach to compare changes in metabolites within multiple sample groups, along with an automated algorithm to facilitate the process. The software introduces a novel tool to visualize volcano plots, called Parallel Fold Change (PFC) plot. Unlike current software solutions, PFC enables researchers to easily process their large omics data sets to compare various biological networks. The PFC plot is an efficient tool for analyzing and interpreting complex biological comparisons and it helps researchers to efficiently map omics pathways.  Fig 1: This figure illustrates a Parallel Fold Change (PFC) plot and demonstrates the parallel comparison of multiple samples in metabolomics. The tool examines the fold-change patterns of 45 metabolites across 16 scenarios involving 8 genotypes and 3 treatments. Using ShowMEPATH, researchers can identify detailed patterns within biological experiments, with the ability to hover over lines in the PFC plots for seamless access to KEGG modules or pathways, thereby streamlining the exploration of related biological information