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Microbial-Induced Barriers To Striga Parasitism

Researchers at the University of California, Davis have discovered an Arthrobacter bacterial strain that promotes suberization of the endodermis in sorghum roots. Suberin, a poly-fatty acid polymer, acts as a physical barrier in sorghum roots, helping to prevent infection by the parasitic plant Striga hermonthica, a significant threat to sorghum production. These microbial-based solutions offer a cost-effective and easily deployable strategy to manage Striga infection in the predominantly smallholder farmer-driven sorghum cultivation of sub-Saharan Africa.

O-Acetyl Glycosphingosines and Gangliosides, as well as Their N-Acetyl Analogs

Researchers at the University of California, Davis have developed a technology providing the creation of stable analogs of glycosphingosines and gangliosides containing O-acetylated sialic acid for extensive biological and medical applications.

Affinity Peptides for Diagnosis and Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 and Zika Virus Infections

Researchers at the University of California, Davis have developed a technology to expedite COVID-19 diagnosis and treatment using viral spike protein (S-protein) targeted peptides Zika virus envelop protein.

Substrate And Process Engineering For Biocatalytic Synthesis And Facile Purification Of Human Milk Oligosaccharides (HMOs)

Researchers at the University of California, Davis have developed an innovative method for efficient, high-yield production and easy purification of Human Milk Oligosaccharides (HMOs) using a Multistep One-Pot Multienzyme (MSOPME) process.

Legionaminic Acid Glycosyltransferases for Chemoenzymatic Synthesis of Glycans and Glycoconjugates

Researchers at the University of California, Davis have developed a method for preparing a glycan product containing a nonulosonic acid moiety by means of legionaminic acid transferase fusion proteins

Artificial Intelligence-Based Evaluation Of Drug Efficacy

Researchers at the University of California, Davis have developed a method of using artificial intelligence for assessing the effectiveness or efficacy of drugs that is cheaper, faster, and more accurate than commonly used assay analyses.

Polysaccharide A-Based Particulate Systems For Attenuation Of Autoimmunity, Allergy and Transplant Rejection

Researchers at the University of California, Davis have developed a customizable polysaccharide that can be added to nanoparticles to reduce their rejection by the human immune system.

Psychoplastogens For Treating Hearing-Related Disorders

Researchers at the University of California, Davis, have developed a novel approach to treat hearing-related disorders with a new type of psychoplastogen that can increase the synapse density in the ear, correlating with hearing ability.

Generalizable and Non-genetic Approach to Create Metabolically-active-but-non-replicating Bacteria

Researchers at the University of California, Davis have developed a method to stop bacterial growth while maintaining desirable metabolic functions for therapeutic and biotechnological applications.

Camellia Sinesis Rapid Growth Platform

Researchers at the University of California Davis have developed a rapid growth platform that aims to decrease crop production time, allow for tunable sensory attributes, and decrease carbon emissions.

Epigenetic Prevention and Treatment of CDKL5 Deficiency Disorder

Researchers at the University of California, Davis have developed a targeted epigenetic approach for the prevention and treatment CDKL5 deficiency disorder.

Biomimetic Chemical Compounds for Capturing Carbon Dioxide from Power Plant Stacks and the Atmosphere

Researchers at the University of California, Davis have developed synthetic biochemical compounds that capture carbon dioxide from the atmosphere or sources such as power plants. These new derivatives mimic how some plants capture carbon dioxide from the air and use it for photosynthesis.

Vascular Anastomosis Device

Researchers at the University of California, Davis have developed a surgical device to facilitate vascular anastomosis procedures with enhanced ease and speed.

Integrin Binding to P-Selectin as a Treatment for Cancer and Inflammation

Researchers at the University of California, Davis have developed a potential drug target for cancer and inflammation by studying the binding of integrins to P-selectin.

Modulating MD-2-Integrin Interaction for Sepsis Treatment

Researchers at the University of California, Davis have developed a potential therapeutic treatment for sepsis by modulating the interaction between integrins and Myeloid Differentiation factor 2 (MD-2).

Tumor-Suppressing Growth Factor Decoy

Researchers at the University of California, Davis have developed dominant-negative FGF2 antagonists that suppress angiogenesis and tumor growth.

Deep Learning-Based Approach to Accelerate T cell Receptor Design

Researchers at the University of California, Davis have developed a deep learning simulation model to predict mutated T-cell receptor affinity and avidity for immunotherapy applications.

Positive Allosteric Modulators Target TRPV1 with Analgesic Effects

Researchers at the University of California, Davis have developed de novo positive allosteric modulators (PAMs) that bind to TRPV1 proteins involved with pain-sensing in order to provide analgesic effects.

Conjugates That Combine HDAC Inhibitors and Retinoids into Disease Preventatives/Treatments

Researchers at the University of California, Davis have developed methods for creating compositions with the potential to prevent or treat cancer or metabolic diseases. These compositions combine conjugates with covalently linked HDAC inhibitors and retinoids.

Multiplex Epigenetic Editing using a Split-dCas9 System

Researchers at the University of California, Davis have developed a new epigenetic editing system that overcomes packaging limitations of viral delivery systems and can be used for multiplexed epigenetic editing of a genome.

One-Pot Multienzyme Synthesis of Sialidase Reagents, Probes and Inhibitors

Researchers at the University of California, Davis, have developed an environmentally friendly one-pot multienzyme (OPME) method for synthesizing sialidase reagents, probes, and inhibitors.

Small Molecules for Treating Clostridium perfringens-related Bacterial Infections

Researchers at the University of California, Davis have developed a method of treating infections caused by Clostridium perfringens bacteria - via inhibiting the bacteria’s normal quorum sensing processes.

DNA-based, Read-Only Memory (ROM) for Data Storage Applications

Researchers at the University of California, Davis have collaborated with colleagues at the University of Washington and Emory University to develop a DNA-based, memory and data storage technology that integrates seamlessly with semiconductor-based technologies and conventional electronic devices.

Gene Editing for Improved Plant Characteristics via Modulation of Suberin Regulators

Researchers at the University of California, Davis have identified specific genetic modifications to plants that impart a variety of advantages based on modulating the presence of suberin

Using Escherichia coli to Produce Human Milk Oligosaccharide Lactodifucotetraose

Researchers at the University of California, Davis have developed a method for producing human milk oligosaccharide lactodifuctotetraose (LDFT) using E. coli.

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