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INTEGRATED OPTICAL PEEL AWAY PLEUROSCOPIC TROCAR FOR USE IN PLEUROSCOPIC AND THORACIC PROCEDURES
Brief description not available
Leveraging microbiome bacteria, bacterial modulators, and novel microbial species for prevention, diagnosis, and treatment of inflammatory diseases, respiratory system infections, and premature birth
The following technologies encompass a portfolio of microbiome-centric inventions intended to address unmet diagnostic and treatment needs in the areas of inflammatory disease and respiratory system infections, including prevention in infants.
MicroRNA regulation of airway mucins for treatment of lung diseases
This invention describes a novel therapeutic microRNA target regulating mucus production for the management of symptoms caused by a range of lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and the common cold. Recently, a specific miRNA, along with its highly homologous family members, has been shown to be dysregulated in asthmatic subjects. To modulate the effect of these miRNAs, antagomirs (which target specific endogenous miRNAs and dampen their effect) or miRNA mimics can be administered via an inhaler, allowing for the regulation of mucus production. This invention is at the preclinical stage, and in vivo testing in a mouse model of asthma has shown that treatment with a specific miRNA antagomir results in a significant reduction of airway mucus production. While there are currently no effective therapies targeting mucus production in the airways, miRNAs are a promising new avenue for therapeutic intervention as they are fast-acting and reversible.
Small Molecule Pendrin Inhibitors for Treatment of Inflammatory Airway Diseases and Diuretic Resistance
Small molecule pendrin inhibitors for treating inflammatory lung diseases.
“CT Mucus Score” - A New Scoring System that Quantifies Airway Mucus Impaction Using CT Scans
A novel method to measure airway mucus plugging using CT images from patients with asthma or chronic obstructive pulmonary disease (COPD) patients.
Novel Gut Microbiome-based Diagnostic and Therapeutic for Neonates at Risk of Childhood Atopy and Asthma
UCSF researchers have developed a novel gut microbiome-based diagnostic test and targeted treatment for early-life identification of atopy or asthma risk in children.
Potent TMEM16A Small Molecule Treatment for Inflammatory and Reactive Airway Diseases, Asthma, Hypertension, Pain and Cancer
A novel class of 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides (AACTs) as potent TMEM16A inhibitors
Novel Use of Chitinases for Treatment of Lung Inflammatory and Fibrotic Diseases
A novel approach for the treatment of lung inflammatory and fibrotic diseases by increased or repaired chitinase function in lung tissues
METHOD FOR DETECTING AND TREATING NASAL AND LUNG DYSBIOSIS PATIENTS WITH MICROORGANISMS
This invention uses sequencing of microbiota community for diagnosis and treatment of lung and nasal dysbiosis.
CFTR potentiators and correctors and bifunctional (corrector/potentiator) compounds for treatment of Cystic Fibrosis
Successful web-based smoking cessation program yields 20% abstinence rates at one year.