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A Novel Method to Generate Specific and Permanent Macromolecular Covalent Inhibitors
UCSF researchers have invented a novel method to generate covalent macromolecular inhibitors. This strategy allows a peptide inhibitor to bind to its target protein specifically and irreversibly through proximity-enabled bioreactivity.
Novel Small Molecule CFTR Activators for the Treatment of Constipation
This invention identifies novel small molecule activators of CFTR (cystic fibrosis transmembrane conductance regulator) that can be developed as effective therapies to treat constipation.
Novel ELISA assay to detect SULF2 in patient samples
This ELISA technique detects Sulfatase2 (SULF2), an extracellular heparan sulfate-degrading enzyme that is overexpressed in many cancers. Furthermore, this technique can potentially serve as a diagnostic for cirrhosis.
SMALL MOLECULE INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS TO TREAT SECRETORY DIARRHEA
Brief description not available