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A Novel Method to Generate Specific and Permanent Macromolecular Covalent Inhibitors
UCSF researchers have invented a novel method to generate covalent macromolecular inhibitors. This strategy allows a peptide inhibitor to bind to its target protein specifically and irreversibly through proximity-enabled bioreactivity.
Novel ELISA assay to detect SULF2 in patient samples
This ELISA technique detects Sulfatase2 (SULF2), an extracellular heparan sulfate-degrading enzyme that is overexpressed in many cancers. Furthermore, this technique can potentially serve as a diagnostic for cirrhosis.
SMALL MOLECULE INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS TO TREAT SECRETORY DIARRHEA
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