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Retractable Step Cannula For Brain Delivery Of Therapeutics

An adjustable step cannula to minimize therapeutic agent leakage and maximize on-target drug delivery. This new cannula design improves brain drug delivery over current fixed-length step cannulas.

Automated Jugular Venous Pressure Measurement

The clinical exam for measuring jugular venous pressure (JVP), a measurement used to assess heart function has not substantially changed since the 1950s. This invention is a novel device to calculate JVP using accelerometers. This technology allows for more accurate and automated methods for measuring JVP, eliminating the need for a clinical exam.

Method for fabricating micron-scale stepped needles intended for the insertion of devices

This invention is a novel method for fabricating needles with stepped ends. The method uses a brazing technique to achieve a fine stepped needle meant for delivering probes into tissue.   This method creates needles strong enough to be used in neural surgery, but thin enough (<15 um) to create a very minimal entry wound.

Omnidirectional MRI Catheter Resonator for Interventional Procedures

This invention describes an orientation-independent device that can create bright and highly localized signal enhancement during magnetic resonance imaging.

Tracheostomy Alarm for Accidental Decannulation

This invention describes a reusable alarm for sensing accidental tracheostomy decannulation.

Deployable Applicators for Ultrasound Therapy

This invention is a modified catheter-based therapeutic ultrasound device with a novel combinatorial assembly of ultrasonic sources, deployable acoustic reflectors, and a fluid lens intended for the delivery of acoustic energy to target tissue. This assembly overcomes restrictions on dimensions required for minimally-invasive surgical introduction into a body cavity or lumen, and when deployed improves depth and range of treatment delivery for hyperthermia, thermal ablation, drug delivery, or sonotherapy.

Redesigning the Hub Cap to Decrease Central Line Associated Blood Stream Infections

This is a novel mechanism for preventing infections in catheter hubs used in central lines.

Closed-Loop Stimulation Device for Enhancing Motor Function After Stroke

This novel brain stimulation device enhances motor function after stroke by modulating the neural network to be more excitable in a task-dependent manner.

System And Method For Rapid Automated Head Computed Tomography Analysis

This invention is a novel, automated method to rapidly detect and locate neurological emergencies such as acute intracranial hemorrhage on head computed tomography (CT) images using deep learning technology.

MR-guided Thermal Ablation Device for Pancreatic Tumors

An endoluminal ultrasound therapy device capable of operation under real-time MRI visualization for precision directed pancreatic tumor ablation.

Unconstrained Radiosurgery with Greatly Improved Dosage Fall Off

This invention describes a novel approach to radiosurgery that removes current constrains on stereotactic radiosurgery to reduce exposure of healthy brain tissue to radiation, thereby minimizing off-target brain damage.

A Real-time Intraoperative Fluorescent Imaging Device for Guided Surgical Excision of Microscopic Residual Tumors

This novel real-time imaging device can provide precise and rapid pathological imaging information of the tumor area by utilizing fluorescent or luminescent markers within the body to ensure complete surgical resection.

A Novel Method of Removing Stimulation Artifacts (SA) from Multichannel Electrical Recordings

This technology is a novel algorithm that can significantly remove stimulation artifacts (SA) from electrophysiological recording devices used for neuroscience research and/or clinical therapeutics.

Multi-purpose Delivery Catheter for Injecting a Substrate into a Tissue

A catheter with a retractable needle along a camera, a balloon, and/or a vacuum port to inject material or a device into a tissue of a patient

Measurement Of Blood Flow Dynamics With X-Ray Computed Tomography: Dynamic Ct Angiography

This invention identifies a method to accurately measure flow dynamics, such as velocity and volume, from Computed Tomography scans of blood vessels in a patient.

Method for Reducing Nephrotoxic Effects Induced By Radiographic Contrast Material

A low frequency ultrasound-based method to minimize nephrotoxicity induced by radiographic contrast media (e.g. contrast agent or dye) when using diagnostic tests such as MRI, CT scans, and angiograms.   

An Automated, Minimally-invasive Neural Interface System Providing the Means for Scalable Electrode Implantation

This invention provides an automated, high-throughput, minimally-invasive system to insert electrodes within the brain and other parts of the central nervous system (CNS). The system provides a means for inserting these electrodes within the brain with minimal to no disruption of the blood brain barrier (BBB). This feature is critical, as neural electrode failure is closely associated with inflammation resulting from the disruption of the BBB. Furthermore, this system will allow the implantation of electrodes within the CNS at a much higher density than current standards.

PRO- RESOLVING MEDIATORS AND DEVICES FOR THERAPEUTIC MODULATION OF BLOOD VESSEL HEALING

This invention consists of the use of a novel class(es) of anti-inflammatory and pro-resolving mediators derived from ω-3 polyunsaturated fatty acids, as well as devices designed to deliver these mediators directly to blood vessel for therapeutic modulation of blood vessel healing.

NOVEL DRUG DELIVERY DEVICE FOR PATIENTS AT RISK FOR BREAST CANCER

This novel device enables the localized, controlled delivery of chemopreventative agents to the breast tissue of patients at risk for developing breast cancer. 

Nanophotonics-Based Implantable Iop-Sensor With Remote Optical Readout

This invention enables the remote automated monitoring of intraocular pressure in patients or animal models to inform glaucoma treatment and the development of new therapeutics for glaucoma.

Decoding Speech Sounds From The Human Brain For A Communication Neuroprosthetic Device

Speech requires the precise movement of the lips, tongue, and jaw in order to produce the wide variety of sounds that comprise any given language.  These movements are controlled by a small region on the surface of the brain known as the ventral sensorimotor cortex (vSMC).                 Certain neurodegenerative disorders such as Lou Gehrigs’s disease/ALS or multiple sclerosis, along with paralysis due to injury or stroke, can leave individuals unable to speak due to their inability to move the required muscles.  In many of these cases, the patients still retain the cognitive ability to compose speech and visualize the muscle movements required to generate that speech.  This inability to communicate is particularly acute for a subset of patients suffering from locked-in syndrome (LIS).  These individuals are fully conscious but are only, at best, able to move their eyes.  The inability of these patients to effectively communicate is compounded by the fact that stroke-related LIS has 5- and 10-year post-onset survival rates of over 80% [1].  Various speech generating devices have been developed to assist LIS patients and others with severe motor-related speech defects.  However, none of these devices have been able to offer efficient communication since they are limited by the speed at which patients can select individual letters and/or words by movement of a finger or an eye.   Despite these limitations, the market for speech generating devices is projected to grow to $505M by 2018.

NOVEL CARDIAC CATHETER

Cardiac catheterization, angioplasty, and related catheter-based interventions are known as the most significant discoveries made in cardiovascular medicine. Currently, >700,000 cardiac catheterizations and >600,000 percutaneous coronary interventions (PCI) are performed annually in the United States. Such techniques have evolved over the past century, providing researchers and physicians a better understanding of basic cardiovascular biology and have enabled accurate diagnoses, effective treatments of major cardiac diseases. Cardiac catheterization is a fundamental medical procedure used to diagnose and treat cardiovascular disease, including heart attack and stroke, the number one killer of men and women in the United States. Cardiac catheterization is a technically difficult procedure, requiring the skills of experienced medical physicians. Physicians are often faced with anatomical challenges, making it difficult to successfully execute cardiac catheterizations. In order to successfully complete the procedure, the equipment must traverse tortuous arteries and anatomical anomalies in order to reach the heart (e.g. tortuous subclavian arteries in trans-radial cardiac catheterization; tortuous iliac arteries in trans-femoral cardiac catheterization). Thus, there is a significant need for improved catheter design that overcomes such challenges without compromising medical benefit.

Modular Cell and Drug Delivery Cannula System

The use of cell transplantation in the brain shows great promise for the treatment of human neurological diseases, such as Parkinson's disease or stroke. Indeed, pre-clinical studies in animal models have shown significantly improved neurological function following cell grafting. However, in human trials the results have been considerably more variable. This has, in part, been attributed to concerns with poor cell distribution within the target area. A further issue that has arisen with the challenge of scaling up from animal models to humans is the increase in the number of transcortical penetrations required to deliver therapeutic agents. For surgical cell transplantation approaches, cell sedimentation and impaired graft viability are also concerns that need to be addressed to optimize the use of this therapeutic avenue.

Novel, less invasive biomarker to detect and monitor Parkinson's disease and other movement disorders

Parkinson’s disease (PD) and primary dystonia  are common brain disorders that affect movement. Performing daily activities becomes increasing difficult and medication is insufficient for treatment of symptoms as severity increases. The best current technology for treatment of these disorders is deep brain stimulation (DBS) which uses stimulator electrodes inserted in the basal ganglia to alter electrical signaling. Determination of optimal stimulation is based on a “trial & error” approach and there is no accurate way to guide the therapy.  Stimulation is performed as an “open loop”, meaning that there is no brain signal that can be used to monitor the effectiveness of therapy and control the stimulation automatically. Hence, programming of the stimulation requires several time consuming appointments before the optimal setting is determined; thus making it difficult to achieve immediate symptom relief. Identification of a novel method to guide DBS therapy for PD and dystonia is greatly needed.

Robotic Needle Ablation Tool and Securement Device

Tumors have historically been removed through surgical intervention but recently many tumors are instead treated with needle tumor ablation. This is a procedure in which needles are inserted manually via a small skin incision, through the muscle and inner tissue layers, towards a tumor. The tumor is destroyed by applying energy through the needle (high frequency heat in the case of radiofrequency ablation and cold energy in the case of cryotherapy). The needle’s trajectory in relation to the patient’s body must be carefully monitored by CT or MRI scans to ensure that the needle does not damage collateral tissues such as blood vessels or other organs. Any displacement of the needle during the procedure may not only result in needle placement error, but could potentially lead to bleeding or rupture of the tumor and the in-situ release of tumor cells. Improvements in CT scan and MRI scan image resolution have advanced needle ablation therapy, allowing even small tumors to be easily detected. However, the need for continual imaging by CT scan results in the use of increased doses of radiation. Indeed, doses can be between 100 to 500 times greater than those used for conventional radiography. Furthermore, as small changes in needle positioning require repeat imaging, the operator must vacate the CT suite many times, adding a significant time delay to the procedure.

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