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Neural Implant Platform for Direct and Large Surface-area Access to Brain

This invention is a neural implantation platform permitting large scale recording of brain activity, suitable for both animals and humans. The use of advanced silicone materials in the design allows for greater access to brain surface area than currently existing implantation platforms.

NOVEL BRAIN TECHNOLOGY FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS USING ELECTRICAL STIMULATIONS

This invention is a novel technology developed to treat a patient’s neurological and/or psychiatric conditions. It consists of a system of implantable devices and computational algorithms that not only has autonomous control in sensing and stimulation of electrical signals in the patient’s brain, but also enables interactions with the external environment, thereby enhancing training and learning.

Biomarker of Dyskinesia to Customize Medication or Deep Brain Stimulation for Parkinson's Disease Patients

This invention has provided methods for detecting dyskinesia in Parkinson’s disease patients and provided a way to titrate current treatment to maximize benefits while minimizing side effects.

Novel Methodology To Convert Magnetic Resonance Imaging Scan Data To Be Used In Proton Beam Therapy

This invention is a novel model that uses magnetic resonance imaging (MRI) information to more accurately determine the irradiation area using proton beam therapy (PBT) for oncological treatment.

Percutaneous Arteriovenous Fistula For Dialysis Access

This implantable medical device can be used to create an arteriovenous fistula (AVF) percutaneously, in a clinic based procedure. The AVF improves clinical outcomes for  patients  on hemodialysis.

Retractable Step Cannula For Brain Delivery Of Therapeutics

An adjustable step cannula to minimize therapeutic agent leakage and maximize on-target drug delivery. This new cannula design improves brain drug delivery over current fixed-length step cannulas.

Automated Jugular Venous Pressure Measurement

The clinical exam for measuring jugular venous pressure (JVP), a measurement used to assess heart function has not substantially changed since the 1950s. This invention is a novel device to calculate JVP using accelerometers. This technology allows for more accurate and automated methods for measuring JVP, eliminating the need for a clinical exam.

Method for fabricating micron-scale stepped needles intended for the insertion of devices

This invention is a novel method for fabricating needles with stepped ends. The method uses a brazing technique to achieve a fine stepped needle meant for delivering probes into tissue.   This method creates needles strong enough to be used in neural surgery, but thin enough (<15 um) to create a very minimal entry wound.

Omnidirectional MRI Catheter Resonator for Interventional Procedures

This invention describes an orientation-independent device that can create bright and highly localized signal enhancement during magnetic resonance imaging.

Deployable Applicators for Ultrasound Therapy

This invention is a modified catheter-based therapeutic ultrasound device with a novel combinatorial assembly of ultrasonic sources, deployable acoustic reflectors, and a fluid lens intended for the delivery of acoustic energy to target tissue. This assembly overcomes restrictions on dimensions required for minimally-invasive surgical introduction into a body cavity or lumen, and when deployed improves depth and range of treatment delivery for hyperthermia, thermal ablation, drug delivery, or sonotherapy.

Redesigning the Hub Cap to Decrease Central Line Associated Blood Stream Infections

This is a novel mechanism for preventing infections in catheter hubs used in central lines.

Closed-Loop Stimulation Device for Enhancing Motor Function After Stroke

This novel brain stimulation device enhances motor function after stroke by modulating the neural network to be more excitable in a task-dependent manner.

System And Method For Rapid Automated Head Computed Tomography Analysis

This invention is a novel, automated method to rapidly detect and locate neurological emergencies such as acute intracranial hemorrhage on head computed tomography (CT) images using deep learning technology.

MR-guided Thermal Ablation Device for Pancreatic Tumors

An endoluminal ultrasound therapy device capable of operation under real-time MRI visualization for precision directed pancreatic tumor ablation.

Unconstrained Radiosurgery with Greatly Improved Dosage Fall Off

This invention describes a novel approach to radiosurgery that removes current constrains on stereotactic radiosurgery to reduce exposure of healthy brain tissue to radiation, thereby minimizing off-target brain damage.

A Real-time Intraoperative Fluorescent Imaging Device for Guided Surgical Excision of Microscopic Residual Tumors

This novel real-time imaging device can provide precise and rapid pathological imaging information of the tumor area by utilizing fluorescent or luminescent markers within the body to ensure complete surgical resection.

A Novel Method of Removing Stimulation Artifacts (SA) from Multichannel Electrical Recordings

This technology is a novel algorithm that can significantly remove stimulation artifacts (SA) from electrophysiological recording devices used for neuroscience research and/or clinical therapeutics.

Multi-purpose Delivery Catheter for Injecting a Substrate into a Tissue

A catheter with a retractable needle along a camera, a balloon, and/or a vacuum port to inject material or a device into a tissue of a patient

An Integrated Neo-Vagina Dilator and Douche for Neo-Vaginal Space

This technology describes a flexible neo-vaginal dilator, integrated with a douching system for facile irrigation, to aid in the creation of new vaginal space in trans- and cis-gendered women.

Measurement Of Blood Flow Dynamics With X-Ray Computed Tomography: Dynamic Ct Angiography

This invention identifies a method to accurately measure flow dynamics, such as velocity and volume, from Computed Tomography scans of blood vessels in a patient.

Method for Reducing Nephrotoxic Effects Induced By Radiographic Contrast Material

A low frequency ultrasound-based method to minimize nephrotoxicity induced by radiographic contrast media (e.g. contrast agent or dye) when using diagnostic tests such as MRI, CT scans, and angiograms.   

An Automated, Minimally-invasive Neural Interface System Providing the Means for Scalable Electrode Implantation

This invention provides an automated, high-throughput, minimally-invasive system to insert electrodes within the brain and other parts of the central nervous system (CNS). The system provides a means for inserting these electrodes within the brain with minimal to no disruption of the blood brain barrier (BBB). This feature is critical, as neural electrode failure is closely associated with inflammation resulting from the disruption of the BBB. Furthermore, this system will allow the implantation of electrodes within the CNS at a much higher density than current standards.

PRO- RESOLVING MEDIATORS AND DEVICES FOR THERAPEUTIC MODULATION OF BLOOD VESSEL HEALING

This invention consists of the use of a novel class(es) of anti-inflammatory and pro-resolving mediators derived from ω-3 polyunsaturated fatty acids, as well as devices designed to deliver these mediators directly to blood vessel for therapeutic modulation of blood vessel healing.

NOVEL DRUG DELIVERY DEVICE FOR PATIENTS AT RISK FOR BREAST CANCER

This novel device enables the localized, controlled delivery of chemopreventative agents to the breast tissue of patients at risk for developing breast cancer. 

Nanophotonics-Based Implantable Iop-Sensor With Remote Optical Readout

This invention enables the remote automated monitoring of intraocular pressure in patients or animal models to inform glaucoma treatment and the development of new therapeutics for glaucoma.

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These technologies are part of the UC QuickStart program.