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A Novel Method to Prevent Postsurgical Cardiac Adhesions Using Oxime Crosslinked Hydrogels

An adhesion is a band of scar tissue that binds two parts of tissue that are not normally joined together. Adhesions may appear as thin sheets of tissue similar to plastic wrap or as thick fibrous bands. The tissue develops when the body's repair mechanisms respond to any tissue disturbance, such as surgery, infection, trauma, or radiation. Although adhesions can occur anywhere, the most common locations are within the stomach, the pelvis, and the heart Two main approaches exist for reducing or attempting to prevent cardiac adhesions: pharmacological therapy and physical barriers. Drugs that prevent or reverse adhesion processes disrupt biochemical pathways of inflammation and fibrin deposition. Unfortunately, these processes are also vital for wound healing. Achieving adequate drug concentration at the site of action, especially for ischemic tissues, is also challenging. A more viable approach is the use of a physical barrier after surgery to prevent fusion of the heart to surrounding tissues. The barriers can be either preformed membranes or injectable hydrogels (fast gelling liquids). Preformed anti-adhesive materials need to be cut before application to the tissue, and must be sutured into place to prevent slippage. While a variety of different materials have been investigated in animals and humans, no materials, to date, have been capable of preventing adhesion formation post-cardiac surgery.

Efficient Nebulizer

Brief description not available

Method For Fabricating Two-Dimensional Protein Crystals

2D crystalline materials possess high surface area-to-volume ratios, light and can be very porous. These properties have rendered synthetic 2D materials immensely attractive in applications including electronics, sensing, coating, filtration and catalysis. The rational design of self-assembling 2D crystals remains a considerable challenge and a very active area of development. The existing methods for the bottom-up fabrication of biological or non-biological 2-D crystalline materials are not generalizable and scalable. 2D protein design strategies, in particular, require extensive computational work and costly protein engineering. In addition, these strategies have low success rates, the resulting materials contain large defects, and are multi-layered and therefore not appropriate for scaling or materials-applications. Moreover, these strategies often require the presence of lipids for supported assembly.

Novel Electrolytes via Compressed Gas Solvent

Brief description not available

Method Of Synthesizing Tetrazines

Nitrogen-rich tetrazines, have broad applications in biochemistry including small-molecule imaging, genetically targeted protein tagging, post-synthetic DNA labeling, nanoparticle-based clinical diagnostics, in-vivo imaging, as well as significant use in materials science, coordination chemistry, and the production of high energy materials such as those used in specialty explosives research. Among other uses, tetrazines can serve as coupling agents for molecular imaging compounds such as fluorophores or magnetic contrast agents, or even as ligands for metal catalysts or inorganic materials such as metal-organic frameworks. Tetrazines are also valuable synthetic intermediates, and have been elegantly deployed on route to several natural product syntheses. Despite the promise of tetrazines, the lack of convenient synthetic methods is a significant roadblock to their broader use and study.

Improved Materials for Lightweight Armor

Brief description not available

Accurate Patterning of Hydrophobic Materials: Assembly of Organic and Inorganic Components on a Substrate

Presented here is the novel mechanical application of adhesive hydrophobic materials to substrates, the patterning of these materials, and the controlled dip-coating of the resulting patterned substrates to allow the control of the spatial and volumetric attributes of liquid droplets. By controlling the speed with which the substrates are dip-coated, and the viscosity of the polymer bath, fine control over the volumes of liquid that are deposited at particular locations on the substrate is obtained. These techniques may be utilized in a variety of applications including microlens arrays, waveguides, bonding, and fluidic handling.

Sensitive Chemical Sensor To Detect A Broad Range Of Nitrogen-Based Explosives

Detecting ultra trace explosive analytes is important for forensic or counterterrorism  applications as well as for personnel, baggage, or cargo screening.  However, metal detectors frequently fail to detect explosives (such as those in the plastic casing of modern land mines); dogs are expensive and difficult to maintain: and other methods, including gas chromatography coupled with mass spectrometry, surface-enhanced Raman, energy dispersive X-ray diffraction, for example, are highly selective, but are expensive and not easily adapted to a small, low-power package.  Therefore, chemical sensors are preferable to other detection devices.

High Glucose Uptake E. Coli Strain

Brief description not available

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