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Chemoenzymatic Synthesis Of Acyl Coenzyme-A Molecules

Acyl-CoAs is involved in both primary and secondary metabolism; it is an important intermediate molecule for in vitro enzymatic assays in research. Current chemical methods to generate acyl-CoAs rely on chemical ligation of carboxylic acids to commercially available coenzyme A molecule by the use of peptide coupling reagents. These couplings are inefficient and the final product is hard to purify. This process of acyl-CoA synthesis is therefore expensive.

Efficient Nebulizer

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Method For Fabricating Two-Dimensional Protein Crystals

2D crystalline materials possess high surface area-to-volume ratios, light and can be very porous. These properties have rendered synthetic 2D materials immensely attractive in applications including electronics, sensing, coating, filtration and catalysis. The rational design of self-assembling 2D crystals remains a considerable challenge and a very active area of development. The existing methods for the bottom-up fabrication of biological or non-biological 2-D crystalline materials are not generalizable and scalable. 2D protein design strategies, in particular, require extensive computational work and costly protein engineering. In addition, these strategies have low success rates, the resulting materials contain large defects, and are multi-layered and therefore not appropriate for scaling or materials-applications. Moreover, these strategies often require the presence of lipids for supported assembly.

Ultra-thin Metamaterial "Carpet Cloak" Design

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Novel Electrolytes via Compressed Gas Solvent

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Synthetic Matrices for Self -Renewal and Expansion of Stem Cells

Although the applications of stem cells hold promise ranging from drug discovery screening to regenerative medicine, the long term propagation and culturing, while maintaining pluripotency remain a challenge. Currently available substrates for stem cell culture typically involve formulations that are heterogeneous and development of defined substrates are challenging due to the multiplicity of signals that are provided by matrices that are extracellular in nature, such as Matrigel.

Method Of Synthesizing Tetrazines

Nitrogen-rich tetrazines, have broad applications in biochemistry including small-molecule imaging, genetically targeted protein tagging, post-synthetic DNA labeling, nanoparticle-based clinical diagnostics, in-vivo imaging, as well as significant use in materials science, coordination chemistry, and the production of high energy materials such as those used in specialty explosives research. Among other uses, tetrazines can serve as coupling agents for molecular imaging compounds such as fluorophores or magnetic contrast agents, or even as ligands for metal catalysts or inorganic materials such as metal-organic frameworks. Tetrazines are also valuable synthetic intermediates, and have been elegantly deployed on route to several natural product syntheses. Despite the promise of tetrazines, the lack of convenient synthetic methods is a significant roadblock to their broader use and study.


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Aerated Contact Lens Made of Hard Materials

Most of the contact lenses on the market today are made of rigid gas permeable plastics (RGP), hydrogels, or composite silicone-hydrogel materials. An essential property of all contact lenses is sufficient access of the non-vascularized cornea to atmospheric oxygen, a requirement for the health of eyes while wearing contact lens. Contact lenses are normally worn either on the eye cornea (more common, small corneal lenses) or sclera (less common, large size scleral lenses). Scleral contact lenses are more expensive, but have several advantages and are exclusively prescribed to people with certain eye disorders. Scleral lenses are normally machined from rigid gas permeable plastics, whose oxygen permeability practically limits lens thickness to ~0.5 mm. Nevertheless, there are some applications, for which it may be desirable to have scleral lenses of substantially greater thickness, and no rigid optical-grade materials with sufficient oxygen permeability is available for this task at present.

Improved Materials for Lightweight Armor

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Accurate Patterning of Hydrophobic Materials: Assembly of Organic and Inorganic Components on a Substrate

Presented here is the novel mechanical application of adhesive hydrophobic materials to substrates, the patterning of these materials, and the controlled dip-coating of the resulting patterned substrates to allow the control of the spatial and volumetric attributes of liquid droplets. By controlling the speed with which the substrates are dip-coated, and the viscosity of the polymer bath, fine control over the volumes of liquid that are deposited at particular locations on the substrate is obtained. These techniques may be utilized in a variety of applications including microlens arrays, waveguides, bonding, and fluidic handling.

Sensitive Chemical Sensor To Detect A Broad Range Of Nitrogen-Based Explosives

Detecting ultra trace explosive analytes is important for forensic or counterterrorism  applications as well as for personnel, baggage, or cargo screening.  However, metal detectors frequently fail to detect explosives (such as those in the plastic casing of modern land mines); dogs are expensive and difficult to maintain: and other methods, including gas chromatography coupled with mass spectrometry, surface-enhanced Raman, energy dispersive X-ray diffraction, for example, are highly selective, but are expensive and not easily adapted to a small, low-power package.  Therefore, chemical sensors are preferable to other detection devices.

High Glucose Uptake E. Coli Strain

Brief description not available

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