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Synthesis of Lipobactins and Teixobactin Analogues – New Antimicrobial Compositions against Gram-Positive Bacteria

With the discovery of penicillin in the 1940’s, many scientists proclaimed the defeat of infectious diseases which had plagued mankind. However, the remarkable healing power of antibiotics unfortunately invited widespread and indiscriminate use of antibiotics. This misuse and overuse of antibiotics has led to the dramatic rise in antibiotic resistant bacterial strains and increased healthcare costs.

Magnetically Tunable Photonic Crystals Based On Anisotropic Nanostructures

Background: Many companies are venturing into new ways to improve paint technology. Current paramagnetic paint can be applied on anything from building interiors to vehicles so that the color can easily change when electric currents are applied. This nanomaterial paint market is projected to grow to $1.4B by 2017 with many notable end users in the display, chemical and automotive industries.  Brief Description: UCR researchers have discovered photonic crystals that can be easily tuned by changing the magnetic field direction without exertion of power. These novel colloidal crystals have magnetic and anisotropic properties that allow them to reach maximum diffraction intensity at certain angles. This could serve as a platform technology since they can take any suitable material that is susceptible to magnetism and optimize its optical components for assembly into photonic structures.

Highly Scalable, Cost and Time-Efficient Solution Exchange Lithography (SEL) Platform

A highly scalable, cost and time-efficient Solution Exchange Lithography (SEL) platform.

Atom Probe Tomography Method and Algorithm

Most cluster analysis parameters in atom probe tomography (APT) are selected ad hoc. This can often lead to data misinterpretation and misleading results by instrument technicians and researchers. Moreover, arbitrary cluster parameters can have suboptimal consequences on data quality and integrity, leading to inefficiencies for downstream data users. To address these problems, researchers at the University of California, Berkeley, have developed a framework and specific cluster analysis methods to efficiently extract knowledge from better APT data. By using parameter selection protocols with theoretical explanations, this technology allows for a more optimized and robust multivariate statistical analysis technique from the start, thus improving the quality of analysis and outcomes for both upstream and downstream data users.

An Optical System for Parallel Acquisition of Raman Spectra from a 2-Dimensional Laser Beam Array

Researchers at the University of California, Davis have developed a method for acquiring Raman spectra from a plurality of laser interrogation spots in a two-dimensional array. This method can be used for parallel analysis of individual cells or for fast chemical imaging of specimens.

Hemostatic Compositions And Methods Of Use

Wet layered clays used as hemostatic agent to promote blood clotting.

Dry-Eye Formulation

The sensation of ocular discomfort commonly referred to as “dry eye” can be caused by various factors. The principal causative factors are (a) increased tear-evaporation rates attributable to meibomian gland dysfunction and insufficient/unbalanced tear-lipid films; (b) inadequate tear-aqueous production attributable to aging, medical procedures performed on the cornea (e.g., LASIK), or other general health conditions (e.g., autoimmune diseases); (c) environmental irritants (e.g., dust, smoke, wind, sun, or low humidity); and (d) eye strain attributable to extended viewing of computer monitors or other working environment-related factors. There are many different artificial-eye drops marketed and prescribed or recommended by medical practitioners to decrease dry-eye sensations. Unfortunately, all provide only short-term or no effects at all on tear-film stability and evaporation rates. Moreover, many artificial-tear formulations contain petrochemicals, (e.g., mineral oil) which have nothing in common with natural lipids comprising human tear-lipid films and might be potentially harmful to the eye.   Researchers at UC Berkeley have developed bicontinuous microemulsion formulations capable of delivering the components necessary to counteract compromised stability of tear-lipid layers and thus enhance the stability of entire tear films. These bicontinuous microemulsion components disperse spontaneously into a physical state that makes the microemulsion completely miscible with both human tear aqueous and human tear lipids. The components of these microemulsions are chemically identical or very close to natural tear lipids and tear aqueous and thus are completely biocompatible with human tear films. The lipids used in this formulation are biodegradable, and human tear enzymes will be able to metabolize these bicontinuous microemulsion lipids.  

Chemoenzymatic Synthesis Of Acyl Coenzyme-A Molecules

Acyl-CoAs is involved in both primary and secondary metabolism; it is an important intermediate molecule for in vitro enzymatic assays in research. Current chemical methods to generate acyl-CoAs rely on chemical ligation of carboxylic acids to commercially available coenzyme A molecule by the use of peptide coupling reagents. These couplings are inefficient and the final product is hard to purify. This process of acyl-CoA synthesis is therefore expensive.

Reactor with Carbon Fiber Materials for Improved III-Nitride Growth

A reactor for growing high-quality group III-nitride crystals using carbon-carbon fiber composites in low oxygen ambient environments.

Preparation and Modification of Lignin

Researchers at the University of California, Davis, with co-inventors, have developed a process for producing a mesoporous lignin directly from a biorefinery process.

Helmet Apparatus

Traumatic brain injury is a major public health issue in the world, especially as related to sports-related accidents in particular as related to football head injuries. Athletes report almost four million sports-related concussions a year in the U.S. alone. A major portion of head injuries are caused by torque (rotational acceleration) in a collision. Current market approaches do not provide adequate protection against the impact caused by torque. To address this problem, researchers at the University of California, Berkeley, have developed a reusable and effective helmet system with optimal elasticity and flexibility and material structure to accommodate the twisting impact of a collision by the helmet rather than against the head. Experiments in silico suggest significant improvement over the state of the art with respect to linear and angular accelerations.

A Self-Regenerative Hybrid Tissue Structure For 3D fabrication of heart valves, blood vessels and other constructs / Mesh enclosed tissue constructs

Current tissue engineered constructs face drawbacks such as structural vulnerability, functionality, and a lack of mechanical properties. A continual need for a tissue constructs that can resist the physiological forces within the body, while being biocompatible, persists. Researchers at UC Irvine have developed a tissue construct composed of a multi-layered tissue enclosed on a metal mesh that addresses the drawbacks experienced by other developed solutions.

Efficient Nebulizer

Brief description not available

Method For Fabricating Two-Dimensional Protein Crystals

2D crystalline materials possess high surface area-to-volume ratios, light and can be very porous. These properties have rendered synthetic 2D materials immensely attractive in applications including electronics, sensing, coating, filtration and catalysis. The rational design of self-assembling 2D crystals remains a considerable challenge and a very active area of development. The existing methods for the bottom-up fabrication of biological or non-biological 2-D crystalline materials are not generalizable and scalable. 2D protein design strategies, in particular, require extensive computational work and costly protein engineering. In addition, these strategies have low success rates, the resulting materials contain large defects, and are multi-layered and therefore not appropriate for scaling or materials-applications. Moreover, these strategies often require the presence of lipids for supported assembly.

Oxidative CH Activation of Non-Activated Alkanes Using Metal-Organic Frameworks (MOFs) as Catalysts

UCLA researchers in the Department of Chemistry and Biochemistry have developed two novel organic framework-based catalysts used in CH activation during the process of converting methane into acetic acid. These catalysts demonstrate high efficiency and specificity, combined with the great chemical stability and reproducibility seen with organic framework materials.

Design and Synthesis of New Metal-Organic Frameworks (MOFs) With Unique Topologies

UCLA researchers in the Department of Chemistry and Biochemistry have developed a series of Metal-Organic Frameworks (MOFs) with unique topologies, structures, and pore sizes, thereby, making these materials more versatile in applications such as gas storage and separation.

Catalytic Coupling Reactions Using Frameworks with Open-Metal-Sites

UCLA researchers in the Department of Chemistry and Biochemistry have developed a group of novel organic framework-based catalysts used in coupling reactions. These catalysts demonstrate high efficiency and specificity, combined with the great chemical stability and reproducibility seen with organic framework materials.

Reversible Ethylene Oxide Capture in Metal Organic Frameworks (MOFs)

UCLA researchers in the Department of Chemistry and Biochemistry have devised a method to separate and purify gases such as ethylene oxide from gaseous mixtures using functionalized and porous metal-organic, covalent-organic, and zeolitic-imidazolate frameworks.

Reversible Hydrogen Storage Using Metal-Organic Frameworks (MOFs)

UCLA researchers in the Department of Chemistry and Biochemistry have demonstrated the ability of functionalized zeolitic imidazolate frameworks (ZIFs) and covalent organic frameworks (COFs) to store significant amounts of hydrogen gas in a safe and practical manner, with ten-fold greater storage capacity compared to other methods.

Adsorptive Gas Separation of Carbon Dioxide from Methane by Zeolitic Imidazolate Frameworks (ZIFs)

UCLA researchers in the Department of Chemistry and Biochemistry have demonstrated the ability of functionalized zeolitic imidazolate frameworks (ZIFs) to be used in gas separation processes, thereby having industrial applications in natural gas purification and landfill gas separation. 

Planar, Nonpolar M-Plane III-Nitride Films Grown on Miscut Substrates

A method for growing planar nonpolar III-nitride films that have atomically smooth surfaces without any macroscopic surface undulations. 

Ultra-thin Metamaterial "Carpet Cloak" Design

Brief description not available

Solid Solution Phosphors for Use in Solid State White Lighting Applications

A new green- and yellow-emitting phosphor material via solid solution that can be used to create a white light emitting diode. 

A Self-Regenerative Hybrid Tissue Structure For 3D Fabrication of Heart Valves, Blood Vessels and Other Constructs

Researchers at UC Irvine have developed a biocompatible and mechanically stable scaffold for engineering tissues that are capable of self-renewal. The hybrid tissue may be used as replacement heart valve leaflets and may also be used for tissue constructs like blood vessels.

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