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High-Throughput Quantification of Nanoparticle Degradation using Computational Microscopy and its Application to Drug Delivery Nanocapsules

UCLA researchers in the Department of Bioengineering have developed a high-throughput imaging technique that monitors the degradation of nanoparticles in real time.

Frequency Doubled Pulsed Swept Laser

UCLA researchers in the Department of Electrical Engineering have invented a swept source laser that operates in the visible light range with a broad sweeping bandwidth.

Plasmonic Nanoparticle Embedded PDMS Micropillar Array and Fabrication Approaches for Large Area Cell Force Sensing

UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a novel cell force sensor platform with high accuracy over large areas.

Silicon Based Chirped Grating Emitter for Uniform Power Emission

Researchers at the University of California, Davis, have developed a chirped grating emitter with ultra-sharp instantaneous field of view (IFOV) for optical beam-steering applications.

Magneto-Optic Nanocrystalline Oxides Fabrication

Researchers at the University of California, Riverside developed a fabrication technique that is capable of manufacturing highly transparent Magneto-optic oxides with reduced processing times. Their technique employs CAPAD (current activated, pressure assisted densification). Briefly, rare earth material in powder form is exposed to a specific current, which heats the sample (below melting temp). Pressure is then applied to the powder, compressing it into the desired shape. The processing temperature is optimized in order to achieve sufficient density without causing excessive phase changes that would destroy light transparency. This process produces materials quickly (<20 min), which, combined with high magneto-optical properties, promises less expensive, smaller, more portable magneto-optical devices. Fig. 1 Top image is a schematic cross-section of the CAPAD apparatus. The bottom image displays a Dy2O3 (dysprosium oxide) sample processed using this method. The sample is suspended from a magnet. Lasers of various wavelengths still transmit through the sample This indicates that the desired magnetic/optical properties of the material have been preserved. Fig. 2 Graph of measured average grain size and density of Dy2O3 samples versus processing temperature. The graph shows that an ideal processing temperature is 1100˚C, providing the highest packing density and smallest grain sizes.    

Phase Recovery And Holographic Image Reconstruction Using Neural Networks

UCLA researchers from the Department of Electric Engineering have developed a novel microscopy approach that produces phase and intensity images using a single hologram acquired from a lens-free CMOS system with extremely fast deep neural network training algorithm.

High Frequency Digital Frequency Domain Fluorescence Lifetime Imaging System For Applications On Tissues

The technology is a software/hardware combination designed to enhance sampling rate for frequency domain fluorescence lifetime imaging. Fluorescence lifetime imaging microscopy (FLIM) is a technique that uses signals emitted from fluorescent samples to construct images of those samples in near real time. An advantage to FLIM is its ability to image large fields of view, which makes it an attractive option for dynamical measurements of live biological tissues. The higher sampling rate available using this technology will allow for more information to be gleaned from biological samples, which may have a fluorescence band up to 1 GHz, advancing tissue imaging.

Materials for Autonomous Tracking, Guiding, Modulating, and Harvesting of Energetic Emissions

UCLA researchers in the Department of Materials Science and Engineering have developed a novel photo-responsive polymer that can real-time detect, track, modulate, and harvest incident optical signals and a broad range of energetic emissions at high accuracy and fast response rate.

Adiabatic Dispersion-Managed Frequency Comb Generation

UCLA researchers have developed a novel methods and apparatus for the production of chip-scale dispersion-managed dissipative Kerr solitons in frequency combs, and their application in mode-locked and pulsed lasers.

Single-Pixel Optical Technologies For Instantly Quantifying Multicellular Response Profiles

UCLA researchers in the Department of Mechanical & Aerospace Engineering and the Department of Pathology & Lab Medicine have proposed a new platform technology to actuate and sense force propagation in real-time for large sheets of cells.

Focusing And Amplifying Reflectarray Metasurfaces For Stable Laser Cavities

UCLA researchers in the Department of Electrical Engineering have developed a novel design of reflectarray metasurface that focuses and amplifies THz laser beams with record high efficiency and stability.

Laser-Assisted Intraocular Surgical Alignment

UCLA researchers in the department of Mechanical Engineering have developed an automated procedure for aligning a remote center of motion to a surgical incision point for robot-assisted surgeries.

A Method Of Extracting Data From Optical Waveforms

UCLA researchers in the Department of Electrical Engineering have developed an ultrafast optical data acquisition technique using Time-stretch Interferometry for General Electric-field Reconstruction (TIGER).

High Mobility Organic Semiconductors

Brief description not available

Improved Performance of III-Nitride Photonic Devices

Use of uniaxial strain to improve performance in optoelectronic devices.

Polarization Standing Wave Cavity Assisted By Anisotropic Structures

Researchers in the Department of Electrical Engineering have developed a cavity demonstrating resonance through polarization standing waves.

A Combined Microfluidic and Fluorescence Lifetime Imaging(FLIM) Platform to Identify Mammalian Circulating Cancer Cells in Whole Blood

Separating and classifying circulating cancer cells from whole blood using a single cell trap microfluidic platform coupled with label free fluorescence life time imaging.

Energy-Efficient All-Optical Nanophotonic Computing

Researchers at the University of California, Davis, have developed a new computing and signal processing platform based on nanophotonics and nanoelectronics to decrease power consumption and improve overall computing speed with all-optical inputs and outputs.

Repeatable Ultra-Fast Low Jitter Spark Gap

UCLA researchers in the Department of Physics have developed a spark gap using a high dielectric material for pulsed laser applications.

Hybrid Integrated Optical Amplifier

A hybrid integrated optical amplifier that offers a significant reduction in cost, size, weight and power.

An Electro-Optical System with a Computation Model for Scanning Human Body

The invention describes an Electro-Optical instrument and a computational model for functional scanning of human body and recovering its chromophores (water, lipid, oxygenated hemoglobin, and deoxygenated hemoglobin). It is a low cost portable system that integrates frequency domain and continuous wave domain for real time spectroscopic imaging of human tissue.

Sparsity-Based Multi-Height Phase Recovery In Holographic Microscopy

UCLA researchers in the Department of Electrical Engineering have developed a sparsity-based phase reconstruction technique implemented in wavelet domain to achieve more than 3-fold reduction in the number of holographic measurements for coherent imaging of densely connected samples with minimal impact on the reconstructed image quality.

Single Fiber-Based Multimodal Biophotonic Imaging and Spectroscopy Platform

Researchers at the University of California, Davis have developed a highly flexible and reconfigurable optical imaging and spectroscopy platform.

Selective Plane Illumination for throughput three-dimensional time course imaging

The invention is a novel arrangement that provides high throughput 3D time coursing imaging solution. The setup, simply applied to the conventional inverted microscope, not only improves the imaging speed, resolution and field view, but also provides new capabilities for monitoring a much broader range of samples with various thicknesses and nature. These features combined open new frontiers for imaging applications, including tracking the development of cells in tissues, one of the ultimate goals for imaging.

Optical Coherence Tomography Device For Characterization Of Atherosclerosis

The invention is a multimodal imaging system that includes an optical coherence tomography device using a particular laser source for accurate and in-depth imaging. The new technology provides a more accurate and detailed imaging solution that aids in reaching a more accurate assessment for the patient’s condition, thus determining the adequate intervention method. Clearly, providing an accurate atherosclerotic plaque identification and treatment option will contribute significantly to treating cardiovascular diseases, which happens to be a leading cause of death in many countries.

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