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New Method to Increase the Rate of Protein Ligation Catalyzed by the S. Aureus Sortase A Enzyme

UCLA researchers in the Department of Chemistry and Biochemistry have developed a new method to increase the rate of ligation catalyzed by the S. aureus Sortase A enzyme

Fabrication of nano-structures on multiple sides of a non-planar surface

The invention is a breakthrough in the method of fabrication of biomedical devices, making them safer and less infectious. It allows the reproduction of nano-features to one or both side of non-planar biomedical devices. This would improve the cell motility and kill bacteria.

Ultra Light Amphiphilic And Resilient Nanocellulose Aerogels And Foams

Researchers at the University of California, Davis have developed an energy efficient method of producing ultra-light aerogels with excellent dry compressive strength and tunable hydrophobicity by ambient drying of nanocellulose wet gels.

Building blocks for 3D, modular microfluidics

Researchers at the University of CA, Irvine have developed modular microfluidic platforms consisting of microfluidic building blocks that can be connected in various configurations to construct complete microfluidic devices for different applications.

A Micro/Nanobubble Oxygenated Solutions for Wound Healing and Tissue Preservation

Soft-tissue injuries and organ transplantation are common in modern combat scenarios. Organs and tissues harvested for transplantation need to be preserved during transport, which can be very difficult. Micro and nanobubbles (MNBs) offer a new technology that could supply oxygenation to such tissues prior to transplantation, thus affording better recovery and survival of patients. Described here is a novel device capable of producing MNB solutions that can be used to preserve viability and function of such organs/tissue. Additionally, these solutions may be used with negative pressure wound therapy to heal soft-tissue wounds.

Novel Metal Chalcogenides For Pseudocapacitive Applications

UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel metal chalcogenides for pseudocapacitive applications. 

Gate-Induced Source Tunneling Field-Effect Transistor (Gistfet)

UCLA researchers in the Department of Electrical Engineering have developed a novel gate-induced source tunneling field-effect transistor (GISTFET).

A New Methodology For 3D Nanoprinting

Researchers at the University of California, Davis have discovered a novel protocol to enable 3D printing with nanometer precision in all three dimensions using polyelectrolyte (PE) inks and atomic force microscopy.

Manufacturing of Tungsten Scandate Nano-Composite Powder via Sol-Gel Method for High Current Density and Long-Life Cathodes

The researchers at University of California, Davis have developed a new process for manufacturing tungsten scandate nano-composite powder that produces high current density and long-life cathodes for high-power terahertz vacuum electron devices. Scandate tungsten nano-composite cathodes enable advancement of microwave sources that bridge the "Terahertz gap."

Potential Driven Electrochemical Modification of Tissue

Researchers at UC Irvine have developed a minimally invasive technology that uses electrical potentials to perform a variety of to modify and reshape soft tissues such as cartilage

High Performance Thin Films from Solution Processible Two-Dimensional Nanoplates

UCLA researchers in the departments of Chemistry and Materials Science have recently developed a novel material for use in flexible, printed electronics.

Tunable Vapor-Condensed Nano-Lenses

UCLA researchers in the Department of Electrical Engineering have developed an improved and cost-efficient nanolens to visualize nanoparticles and viral particles with 50 fold greater detection and more than 10 fold field-of-view compared to other imaging modalities.

Novel Multivalent Bioassay Reagents

The guiding principle for the creation of biomolecular recognition agents has been that affinity is essential for both strength and specificity.  Monoclonal antibodies, the dominant workhorse of affinity reagents, have mono-valent affinities in the uM-nM range with apparent affinities that can be sub nM with the bi-valency intrinsic in intact immunoglobulin structure.  The avidin-biotin interaction used ubiquitously for biomolecular assembly is femto-molar and both highly specific and essentially irreversible.  High affinity has been proclaimed the essential goal for the selection of useful specific aptamers, though there has been disagreement about a tight coupling of affinity and specificity.  

Self-Latching Piezocomposite Actuator

Brief description not available

Large Area Thermoelectric Module Based on a Non-bulk Semiconductor

Conventional TE module are made of a combination of two types of semiconductors: n-type and p-type. The two types of bulky semiconductor pieces are arranged electrically in series to cover areas specific to different applications. Each semiconductor piece is relatively small because its size is limited by its manufacturing process, therefore a large number of semiconductor pieces are required to cover a large area; and furthermore, both n-type and p-type semiconductors are required because of the way they are assembled in a TE module, which makes it impossible to manufacture a TE module that is practically large and economically inexpensive. An advantage of such conventional TE module is that the open circuit voltage can be increased by connecting a large number of single TE unit in series, but the short circuit current is limited by the cross-section of each semiconductor piece. 

Synthetic Platelets (SynPlats) to Treat Internal & External Bleeding

      Biomaterial nano-particles that mimic the key structural and functional attributes of platelets and have been shown to greatly reduce bleeding time both internally and externally.

Bactericidal Surface Patterns

Brief description not available

Hi-Frequency, Low Power Nanowire Nanoelectrochemical Field-Effect Transistors

Conventional silicon-based transistors face limitations in continued reduced dimensions in order to make electrons move faster. Meanwhile thermodynamics are dictating the amount of power consumed at the off state - by limiting the subthreshold slope of conventional transistors to be at least 60 mV/dec. Motivated by Moore’s Law, the following technology advances the effort to build low power computer logic and memory elements with even more speed.

Real-Time Integrity Monitoring of Reverse Osmosis Membranes

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a novel method of monitoring the integrity and permeability of reverse osmosis membranes in the presence of nanoparticles and other contaminants.

DNA Double-Write/Double Binding Identity For Micro/Nano Lithography and Self-Assembly Nanofabrication

There have been several attempts to use DNA for photolithographic micro/nanofabrication. For example, exposing immobilized DNA in an un-masked area to ultraviolet light (UV) will cause the DNA to lose the ability to hybridize to complementary DNA sequences, whereas the immobilized DNA in the masked areas will retain the ability to hybridize a complementary sequence. Pattern formation can be achieved by using the difference in DNA assembly in the masked and exposed areas. However, there is an unmet need to improve the usefulness of DNA lithography to fashion more finely defined and complex.

Hydrogen-Treated Semiconductor Metal Oxides For Photoelectrochemical Water Splitting

Titanium dioxide (TiO2) has been extensively investigated as a photoanode for photoelectrochemical (PEC) water splitting, because of its favorable band-edge positions, strong absorption, superior chemical stability, photo-corrosion resistance, and associated low cost; however, reported photocurrent densities and photoconversion efficiencies of TiO2 photoanodes are substantially lower than projected.  UC Santa Cruz researchers have developed a strategy which demonstrates that hydrogen treatment can significantly enhanced the photoconversion efficiency of TiO2 materials by improving their donor density and electrical conductivity.

Silicon Nanostructure Detector With Sub-Bandgap Infrared Response

Silicon nanostructures have attracted enormous attention in the past two decades due to their unique optical properties that cannot be observed in their bulk counterparts. However, since intrinsic silicon has negligible response to infrared photons (λ>1.15 μm) with energies lower than its bandgap energy, it poses a great challenge to use silicon as an active absorbing material for infrared photodetection. In order to realize all-silicon CMOS compatible infrared photodetectors, various approaches have been investigated including incorporation of germanium with silicon as the optically responsive element, two photon absorption process, and surface-plasmon Schottky detectors. The success of these earlier approaches has been limited.

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