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Activating HIV Latency Using Drug Encapsulated Nanoparticles

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have devised a novel method to target the HIV virus in patients using nanoparticles loaded with therapeutic agents.

Bioactive Tissue Engineering Scaffolds

Brief description not available

Single-Molecular Homogenous Amplified Detection in Confined Volumes

This novel method detects the concentration of molecules of interest without washing steps or any solid-phase reaction.

On-Demand Drug Release System for In Vivo Cancer Treatment Via Self-Assembled Magnetic Nanoparticles

Researchers at UCLA have utilized magnetothermally responsive self-assembled nanoparticle technology for highly effective in vivo cancer treatment. The present invention will lead to a more personalized and effective approach in the field of cancer treatment.

Method of Making Multicomponent Nanoemulsions

Researchers from UCLA’s Department of Chemistry & Biochemistry have developed a novel method of making deformable, multicomponent oil-in-water nanoemulsions to create a single delivery system for multiple drugs or other insoluble molecules.  

Assessing the Toxic Potential of Materials at the Nanolevel

UCLA researchers in the Department of Medicine have developed a comprehensive cellular toxicological screening protocol to speed up the evaluation and hazard ranking of large categories of engineered nanomaterials; this methodology can also be adapted to perform high throughput screening of redox active nanomaterials with the potential to build predictive toxicological paradigms for regulatory purposes.

Measuring Size Distributions of Small-Scale Objects

Dr. Thomas Mason and colleagues at UCLA have created a kit, method, and algorithm for measuring size distributions and pH-dependent electrophoretic mobility distributions, thereby revealing types of stabilizing surface groups, of dispersions of small-scale colloidal objects, including nanoparticles and nanoemulsions.

'Multiple Waves' Nano Delivery System for Treatment Human Pancreatic Cancer

UCLA researchers from the Department of Medicine have designed a treatment strategy to overcome stromal vascular obstruction in pancreatic ductal adenocarcinoma and enhance drug delivery. 

A Universal Scalable and Cost-Effective Surface Modification for Anti-Fouling Polymeric Membranes

Professors Kaner and Hoek have led the development of a novel surface modification of plastic materials including polymeric thin films used for medical, optical, sensing and separation applications that provides robust resistance to bacterial adhesion, fouling and infection. The technology provides a facile method of making anti-infection and anti-fouling plastic surfaces. The unique chemical modification technique can be performed in aqueous solutions and in very short reaction times (seconds to minutes) suggesting it to be amenable to economical commercial scaleup.  

Silicon Microsystems for High-Throughput Analysis of Neural Circuit Activity

UCLA researchers in the Department of Neurobiology have developed a novel silicon-based neural probe that can simultaneously map neural activity from multiple brain structures.

Improved Treatment of Acute Metabolic Acidosis

Professors Thomas Mason and Jeffrey Kraut in UCLA’s Department of Chemistry and School of Medicine, respectively, have developed improved materials and methods of treating acute metabolic acidosis.

A Supramolecular Approach for Preparation of Size-Controllable Nanoparticles

UCLA scientists have developed a novel supramolecular approach for preparation of size-controlled nanoparticles. Supramolecular nanoparticles prepared by this method were used for diagnostic imaging, gene delivery, and delivery to immune cells. 

Novel Approach for Intracellular Delivery of Biomolecules

Researchers at UCLA have developed a nanowire-based substrate technology for the efficient delivery of biomolecules. The system has clear applications for basic biological research and potentially for the treatment of diseases.

Hydrogel-Supported Lipid Membranes

UCLA researchers have developed a hydrogel-supported lipid bilayer or artificial biomimetic membrane technology for the purposes of durable and long-term incorporation of membrane proteins or biophysical experimentation for drug discovery.

Magnetic Actuation of Nanoparticles for Noninvasive Remotely-Controlled Release of Drug

Researchers at UCLA have developed a novel system that combines mesoporous silica nanoparticles with magnetic nanocrystals as a thermally sensitive means of delivering drugs to targeted cells. The synergistic effect of these materials in providing both heat and drug make this method especially significant as a non-invasive, externally controlled drug delivery system with cancer killing potential.

Mesoporous Silica Nanoparticle Based siRNA/Drug Delivery System

UCLA inventors have developed a novel delivery platform using mesoporous silica nanoparticles (MSNP) that has the ability to deliver both nucleic acids and drugs concurrently. Using this system, clinicians would be able to deliver drugs and nucleic acids that modify the expression of a series of drug resistant genes that may neutralize the effect of a co-delivered drug.

Bioactivation and Surface Properties Modulation of Inorganic Nanoparticles

UCLA investigators have developed a method of allowing inorganic, metallic, and semiconductor particles to take part in biological systems. By attaching a specialized peptide to the surface of an inorganic nanoparticle such as a semiconductor nanocrystal, this invention gives non-biocompatible particles water solubility and bioactivity.

On-Demand Release Of Guest Molecules By Using Mesoporous Silica Nanoparticles Equipped With Nanoimpellers

UCLA inventors have developed a novel approach to site specifically release molecules into living cells using a silica-based nanoparticle that functions as a sealed container. This nanoparticle is readily taken up into cells and contains a photo-triggered impellar that once activated, will result in release of its contents. This unique approach to drug delivery holds strong promise for a number of applications including cancer therapy, as well as antibiotic, and anti-viral drug delivery.

pH-Responsive Nanovalves for On-Demand Release of Guest Molecules

UCLA inventors have developed novel nanovalves that aid in the release of guest molecules, such as anticancer drugs, in response to pH levels.

Antimicrobial Activity of Core-Shell Structured Silver-Mesoporous Silica Nanoparticles

Researchers at UCLA have developed a way to encapsulate antimicrobial nanoparticles inside of mesoporous silica particles to provide a robust method for targeted delivery of nanoparticles into critical areas for antimicrobial and bactericidal applications.

Electrochemically Programmed Assembly of Biological and Chemical Agents

The present invention provides a method to assemble distinct polypeptide sequences and complex chemical compounds on nanoscale solid electrodes. The technology opens the possibility for selectively immobilizing biological and chemical agents at specific nanoscale locations on solid supports.

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