Production of Malarial Surface Proteins in Algae for Use as Transmission Blocking Vaccine Candidates

Tech ID: 23648 / UC Case 2011-360-0

Background

P. falciparum surface proteins have been shown to block transmission of malaria. Producing them in algae results in proteins that are correctly folded and not glycosylated, so they are more similar to the native proteins than those produced in bacterial or mammalian systems. In order to produce them for use as vaccine candidates, they will need to be produced in an inexpensive expression system that does not require much, if any, post-production modification and algae chloroplasts provide a viable approach.

 SAMPLE DATA

 

kihkgguiy
 

 

State Of Development

Proof of concept: Multiple proteins have been produced in algal chloroplasts. Two have been tested and demonstrated correct folding and present the authentic antigen.

Related Materials

Patent Status

Country Type Number Dated Case
United States Of America Issued Patent 9,422,347 08/23/2016 2011-360
 

Contact

Learn About UC TechAlerts - Save Searches and receive new technology matches

Inventors

  • Mayfield, Stephen P.

Other Information

Categorized As