Ultrasound Thermal Imaging
Tech ID: 22594 / UC Case 2012-167-0
BackgroundHyper- and hypothermia therapies for the treatment and destruction of cancerous solid tumors have a long history. During treatment it is essential to accurately monitor tissue temperature to ensure tumor destruction. Typically MRI is used to image the tumor and monitor tissue heating and destruction by high-intensity focused ultrasound (FUS). Unfortunately MRI is very expensive and requires specialized equipment that can operate in a strong magnetic field significantly limiting clinical utilization.
Technology DescriptionUCSD researchers have developed a substantially less expensive device and method than MRI, for direct monitoring of tissue temperature distributions in response to hypo- or hyperthermic therapies. The device uses pulse echo ultrasound to measure the local sound speed in the tissue and to map the sound speed to temperature by the use of a known mapping between sound speed and temperature. These thermal images are generated in seconds and are very useful to monitor thermal therapies.
- hyperthermia and hypothermia therapies applied to tissues to destroy tumors directly or as an adjunct therapy to enhance radio- and chemotherapy.
- The thermal images are generated in seconds;
- The device is less significantly less expensive than MRI; and
- The measurement method is more robust than the existing ultrasound thermometry methods based on speckle tracking or other image-based techniques.
State Of DevelopmentA working prototype has been developed and preliminary feasibility testing on a tissue mimicking phantom maps heating from 25° C to 60° C.
Intellectual Property Info
- Nebeker J, Nelson T. Towards Ultrasound Thermometry with Sound Speed Tomography. 2012 AIUM (American Institute of Ultrasound in Medicine) annual convention abstract.
thermal imaging, hypothermia, hyperthermia, cancer, therapy, echo ultrasound