Method And System For Ultra-High Dynamic Range Nucleic Acid Quantification
Tech ID: 22581 / UC Case 2012-322-0
Nucleic acid quantification is extremely important in the field of biological research and has been used for studies of genes, genomes, chromosomes, and viruses. While current methods for nucleic acid quantification are powerful, new methods may provide researchers with increased accuracy, higher resolution, and a larger dynamic range.
Researchers at the University of California, Irvine have developed a novel device and method that can achieve ultra-high dynamic range PCR over 10-12 orders of magnitude. The device can be used on large sample volumes (50 uL) that contain as little as a single nucleic acid strand to as high as theoretically possible. In addition, the device and method can provide higher dynamic ranges with exceptionally higher resolution and accuracy than any prior methods.
The invention may be used for commercial or medical applications to accurately detect nucleic acids over an extremely high dynamic range from a sample volume of 50 uL or less.
PCR, Nucleic Acid, DNA, RNA, Amplification