Photonic Gene Circuits
Tech ID: 22157 / UC Case 2012-050-0
Brief Description
The ability to optically apply input signals and reconfigure existing gene circuit connections would be transformative for engineering functional gene circuits in complex, naturally occurring living systems. To date, current optical methods to interface living cells have so far relied on genomic modifications to permanently encode living cells with light responsive genes, thus limiting dynamic circuit reconfiguration. On-demand optical circuit reconfiguration can be enabled by resonant optical nanoantennas (herein referred to as biomolecular nanoantennas) functioning as selectively addressable optical receivers and biomolecular emitters of small interfering RNA (siRNA).Researchers at the University of California, Berkeley have for the first time reported the design and implementation of photonic gene circuits constructed using biomolecular nanoantennas as optical inputs to existing circuit connections of living cells. They show that photonic gene circuits are modular, enabling sub-circuits to be combined to form large-scale circuit configurations.
Suggested uses
- Engineering functional gene circuits useful for fundamental bioscience, bioengineering, and medical applications.
- Fundamental bioscience applications: Temporally precise modulation and dynamic reconfiguration of native gene circuits enables studies of native gene circuits in the context of a complete organism.
- Bioengineering applications: Engineer photonic gene circuit components. Molecular computing and biocomputing using photonic gene circuits.
- Medical applications: Probe, identify, and reconfigure malfunctioning gene circuits involved in disease progression and cancer.
Advantages
- Control native gene circuits with light.
- an advance towards engineering functional gene circuits in complex, naturally occurring living systems. Allowing for temporally precise modulation and dynamic configuration of native gene circuits.
- modularity allows for photonic gene sub-circuits to form large-scale circuit configurations on demand.
Patent Status
Patent Pending
Related Materials
Inventors
- Lee, Luke P.
Other Information
Categorized As
Related cases
2012-050-0
Contact
Curt Theisen / curt@berkeley.edu / tel: View Phone Number. Please reference Tech ID #22157.
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