Photonic Gene Circuits
Tech ID: 22157 / UC Case 2012-050-0
Brief DescriptionThe ability to optically apply input signals and reconfigure existing gene circuit connections would be transformative for engineering functional gene circuits in complex, naturally occurring living systems. To date, current optical methods to interface living cells have so far relied on genomic modifications to permanently encode living cells with light responsive genes, thus limiting dynamic circuit reconfiguration. On-demand optical circuit reconfiguration can be enabled by resonant optical nanoantennas (herein referred to as biomolecular nanoantennas) functioning as selectively addressable optical receivers and biomolecular emitters of small interfering RNA (siRNA).
Researchers at the University of California, Berkeley have for the first time reported the design and implementation of photonic gene circuits constructed using biomolecular nanoantennas as optical inputs to existing circuit connections of living cells. They show that photonic gene circuits are modular, enabling sub-circuits to be combined to form large-scale circuit configurations.
- Engineering functional gene circuits useful for fundamental bioscience, bioengineering, and medical applications.
- Fundamental bioscience applications: Temporally precise modulation and dynamic reconfiguration of native gene circuits enables studies of native gene circuits in the context of a complete organism.
- Bioengineering applications: Engineer photonic gene circuit components. Molecular computing and biocomputing using photonic gene circuits.
- Medical applications: Probe, identify, and reconfigure malfunctioning gene circuits involved in disease progression and cancer.
- Control native gene circuits with light.
- an advance towards engineering functional gene circuits in complex, naturally occurring living systems. Allowing for temporally precise modulation and dynamic configuration of native gene circuits.
- modularity allows for photonic gene sub-circuits to form large-scale circuit configurations on demand.
- Lee, Luke P.
ADDITIONAL TECHNOLOGIES BY THESE INVENTORS
- Microfluidic Sample Preparation And Impedimetric Detection Of Small Molecules
- Monodisperse Silk Emulsions And Microspheres
- Low Cost Portable Diagnostic Biomolecular Detection Platform
- Resettable Microfluidic device- Microfluidic Ping Pong (MPP)
- A Porous Microfluidic Spinneret
- Biologically Inspired Self-Activated Building Envelope Regulation (Saber)
- Solar Optics-Based Active Panels (Soap) For Greywater Reuse And Integrated Thermal (Grit) Building Control
- Electrophysiological Cell Cytometry And Sorting
- Integrated Microfluidic Universal Sample Preparation And Preconcentration (Usp) Module
- Surface-enhanced Optical Upconversion Luminescence (SOUL) for Single miRNA Detection
- Nanophotonic Graphene Transistor
- Self-Powered Blood Coagulation Chip For Inr Value And Hematocrit Determination
- Modular Aptazyme-Mediated Signal Transduction Coupled With Chemical Amplification In A Semi-Quantitative, Colorimetric Diagnostic Assay
- Stencil Patterning Method For Generating Highly Uniform Stem Cell Colonies
- Low Cost Integrated Molecular Diagnostic Systems
- Portable Fluidic Actuation