Rapid Generation of Retinal Pigmented Epithelium for Retinal Disease Therapy

Tech ID: 22139 / UC Case 2012-019-0

Brief Description

A novel method for rapid and efficient differentiation of human embryonic stem cells into retinal pigmented epithelium.

Background

Retinal Pigmented Epithelium (RPE) cells can be created from human embryonic and induced pluripotent stem cells. It has been shown, however, that the transformation of these stem cells into RPE is inefficient and very time consuming. Research into degenerative retinal diseases would benefit greatly from a more timely and efficient method for producing RPE from human embryonic stem cells.

Description

Researchers at the University of California, Santa Barbara have developed a novel method for rapid and efficient differentiation of human embryonic stem cells into retinal pigmented epithelium. This method yields RPE in the majority of stem cells treated in only half of the time documented for the most efficient methods. The speed and efficiency of the method gives it the potential to significantly advance the fields of research dealing with the causes and therapies for degenerative retinal diseases (e.g. age-related macular degeneration).

Advantages

  • Highly efficient and rapid conversion of human embryonic stem cells to retinal tissue cells
  • A potentially unlimited source of RPE for transplant therapy from human embryonic and induced pluripotent stem cells

Applications

  • Cellular therapy for degenerative retinal diseases
  • Degenerative retinal disease research  

 

This technology is available for licensing.

Patent Status

Country Type Number Dated Case
Patent Cooperation Treaty Published Application WO2013/184809 12/12/2013 2012-019
 

Additional Patent Pending

Inventors

  • Buchholz, David E.
  • Clegg, Dennis O.

Other Information

Categorized As

Related cases

2012-019-0

Contact

Meaghan A. Shaw / shaw@tia.ucsb.edu / tel: View Phone Number. Please reference Tech ID #22139.

ADDITIONAL TECHNOLOGIES BY THESE INVENTORS

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Tel: 805-893-2073 | Fax: 805.893.5236 | shaw@tia.ucsb.edu

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