A Novel Method to Increase the Perfusion Signal to Noise Ratio (SNR) in Velocity Selective Arterial Spin Labeling for MRI
Tech ID: 22017 / UC Case 2011-312-0
BackgroundThe ideal velocity selective arterial (ASL) method for MRI is one in which the tagging is: (1) continuous, (2) inverts blood, and (3) occurs right at the arterioles before the blood enters the capillary bed and tissue. An inherent advantage of velocity selective arterial spin labeling (VSASL) technique over other ASL methods is property #3—the tagging occurs all the way down the arterial tree to small arterioles, therefore intrinsically insensitive to transit delays and is useful in applications where transit delay can be long, such as perfusion imaging in white matter, and in stroke.
Technology DescriptionUC San Diego researchers have developed a VSASL method to address the first property. In conventional VSASL, the tagging of arterial blood is applied once before imaging and the tagged blood undergoes uniform T1 decay prior to image acquisition. If two or more VSS modules are used, some of the recovered tagged blood will be saturated again at a later time. Multiple VSS modules produces tagging that more closely approximates the ideal situation of being continuous. The tagged blood is therefore closer to saturation at the time of image acquisition, resulting in the improvement of overall tagging efficiency and the signal to noise ratio (SNR). Using two VSS results in an increase of SNR by approximately 20 percent when compared to one VSS module. The UC San Diego method makes VSASL SNR competitive with other ASL methods, while maintaining the inherent insensitivity to transit delays.
AdvantagesMR imaging of perfusion using VSASL with higher SNR, resulting in shorter scan times and/or higher resolution.
State Of DevelopmentThe basic principles have been demonstrated with human volunteers. Inventors are currently working on parameter optimization.
ApplicationsImaging of perfusion in cerebrovascular disease including, but not limited to, stroke, TIA, carotid stenosis, and moyamoya syndrome.
- Eric C. Wong,Matthew Cronin, Wen-Chau Wu, Ben Inglis, Lawrence R. Frank, and Thomas T. Liu, Velocity-Selective Arterial Spin Labeling, Magnetic Resonance in Medicine 55:1334-1341 (2006).
- Guo J, Wong, Increased Tagging Efficiency in Velocity Selective ASL Using Multiple Velocity Selective Saturation Modules, EC, 2011. ISMRM 19th Annual Meeting, Abstract #296.
|United States Of America||Published Application||12-0268126||10/25/2012||2011-312|
|Patent Cooperation Treaty||Published Application||2012/145687||10/26/2012||2011-312|
velocity selective arterial (ASL), velocity selective arterial spin labeling (VSASL), MRI, imaging, stroke, TIA, carotid stenosis, moyamoya syndrome
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