Escherichia Coli Capable of Producing Isobutyraldehyde

Abstract

Researchers at the University of California, Davis have developed strains of Escherichia coli capable of producing the valuable chemical feedstock, isobutyraldehyde. This strain is specifically optimized for the production of isobutyraldehyde.

Full Description

E. coli has long been used for the industrial production of valuable chemicals due to its fast growth rate, well-developed fermentation technology, and tools for genetic modification. In recent year, E. coli has seen great success in the production of many alcohols. However, there has been little effort to optimize E. coli for aldehyde production.

Researchers at the University of California, Davis have developed a novel strain of E. coli capable of producing isobutyraldehyde in high titers without conversion to isobutanol. Aldehydes are reactive compounds useful for chemical feedstocks to generate many additional, more complex molecules. In particular, isobutyraldehyde can be later converted to isobutanol and isobutyrate, or be used to generate polymers.

Applications

• Renewable production of isobutyraldehyde

Features/Benefits

• Improved production of Isobutyraldehyde
• Industrial scale production
• Greatly reduced side product formation
• Potentially useful for production of other aldehydes

Patent Status

Related Materials

• Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity - 06/25/2012
• Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity. Gabriel M Rodriguez and Shota Atsumi. - 11/01/1990

Published Patent Application

Escherichia coli engineered for isobutyraldehyde production. WO 2013192237 A1