Synthesis Of Syrbactin Proteasome Inhibitors

The ability of natural products and other compounds to act as proteasome inhibitors has attracted significant interest because of the wide range of cellular substrates and processes controlled or affected by the ubiquitin-proteasome pathway.

UCR Researchers have achieved the synthesis of novel compounds useful for regulating the ubiquitin-proteasome pathway. They can be prepared in just a few steps, in high efficiency, and in good quantity, as would be needed for a manufacturing process.

Due to the role of the ubiquitin-proteasome pathway in important cellular processes such as apoptosis, and cellular proliferation , the inhibition of the proteasome has been recognized as a useful property for the development novel anti-cancer therapeutics.

In addition to cancer therapy, it is envisioned that molecules that specifically inhibit the proteasome such as those in this invention could have other uses, including as drugs for autoimmune diseases or as agrochemical and possibly antibacterial agents.