A Web-Based Insulin Infusion Calculator (IIC)

Tech ID: 19839 / UC Case 2010-805-0

Background

It is estimated that an average of 38 percent of all hospitalized patients experience hyperglycemia and 32 percent of these patients have no history of diabetes. Hyperglycemia often contributes to undesirable clinical outcomes in critically ill patients. It has been demonstrated that using intravenous insulin to manage glycemia improves clinical outcomes. However, the paper-based, manual protocol used to calculate insulin infusion dosages is complicated to use and subject to human calculation errors and inter-practitioner variability. More importantly, implementation of the paper protocol produces low protocol compliance and results in increased episodes of hypoglycemia when compared to a computer based insulin infusion calculator.

Technology Description

UC San Diego researchers and physicians have developed a software system—an insulin infusion calculator (IIC)—to improve insulin compliance and to reduce the number of calculation errors. To briefly summarize, the invention is a hospital-tested software system designed to achieve desirable blood glucose control and minimize hypoglycemia by automating the calculation for the appropriate insulin dosage for intravenous infusion.

The computerized insulin calculator works by prompting onsite glucose measurements and calculating an intravenous insulin infusion dosage to achieve the therapeutic goal of maintaining blood glucose (BG) levels within the range specified by the unit's medical director (the default setting is 91-150 mg/dL). The system is Web based with access at all bedside computers in the intensive care units and step down telemetry units. It is designed to recognize trends in blood glucose and uses an algorithm to derive a “multiplier” to dictate subsequent insulin dosing.

Advantages

  • Achieving tight glycemic control without increasing episodes of severe hypoglycemia.
  • Improved insulin compliance (from 70 to 88 percent in the UCSD in-house study).
  • Easy to use.
  • Adaptable to each specialty unit/ward for its own defined therapeutic range, insulin sensitivity coefficient (ISC), hypoglycemic level for holding infusion, and the administration of dextrose.
  • The IIC system has been tested in multiple areas of critical care units, including surgical, medical, cardiovasular, and high-risk diabetic woman during pregnancy.

Applications

The IIC can be used for the intensive management of blood glucose levels in various medical settings, from units of SICU, burns, trauma, to the transition and intermediate ward.

State Of Development

More than 700 patients have benefited from the use of IIC software system since its installation on May 2008 at the Division of Trauma, Surgical Intensive Care and Burns at UCSD Hospital.

Other Information

Categorized As

Related cases

2010-805-0

Keywords

insulin infusion, glycemic control, blood glucose, hyperglycemia, hypoglycemia, insulin calculator

Contact

University of California, San Diego Technology Transfer Office / invent@ucsd.edu / tel: View Phone Number. Please reference Tech ID #19839.

University of California, San Diego
Technology Transfer Office

9500 Gilman Drive, MC 0910, La Jolla, CA 92093-0910 | invent.ucsd.edu
Tel: 858.534.5815 | Fax: 858.534.7345 | invent@ucsd.edu