Technology Description

UC San Diego researchers have discovered a cardiac progenitor population that can be expanded and propagated in vitro. The undifferentiated cells express a characteristic subset of phenotypic markers, which allows the cells to be visualized and manipulated. These cells are capable of differentiating in vitro into more than one cell type when selected from mouse or rat hearts.

Applications

This cell population has numerous applications as research tool for stem cell biology and potential therapeutics for cardiac disease settings. These cells are a potential platform for screening for growth and differentiation factors for regenerative medicine in the treatment of myocardial infarction and heart failure. An advantage of these cells in comparison to embryonic stem cells in the setting of cell-based therapies is that this population is less immunogenic than primary embryonic myocytes in xenografts. Additional applications of these cells could include toxicological screening and tissue engineering.

Intellectual Property Info

See international patent application, published 19-Aug-2004 (2004/070013).

Patent Status

Country	Type	Number	Dated	Case
United States Of America	Issued Patent	7,745,113	06/29/2010	2003-140

Other Information

Contact

University of California, San Diego Technology Transfer Office / invent@ucsd.edu / tel: View Phone Number. Please reference Tech ID #19646.

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