A Novel Technique for Fabricating Biomolecular Nano-Arrays Enabling High-DNA Amplification and Sequencing
Tech ID: 19180 / UC Case 2007-085-0
Technology Description
This invention provides a new approach for fabricating high-density nano-arrays for bio-molecules. Researchers used glass slides derivatized with functional groups, then coated them with a thin layer of photo-resist. Conventional photolithography is then used to create high-density wells of sub-micron dimension into which nano-particles conjugated to a single DNA clone are allowed to self-assemble. The small size of the wells prevents more than one molecule from attaching in any given well. The nano-particles remain fixed in their wells through biotin-avidin with the remaining non-specifically bound nano-particles being washed away with the removal of the remaining photo-resist. This leaves a very clean array for high throughput sequencing.
Applications
This technology may be applied to high-throughput genome sequencing, protein array analysis, and bio-sensors.Other Information
This invention has a patent pending.Patent Status
| Country | Type | Number | Dated | Case |
| United States Of America | Published Application | 20100120630 | 05/13/2010 | 2007-085 |
Contact
University of California, San Diego Technology Transfer Office / invent@ucsd.edu / tel: View Phone Number. Please reference Tech ID #19180.
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