Patent Portfolio for Islet Cell Coating Techniques
Tech ID: 11245 / UC Case 1989-160-0
Attempts to transplant organ tissues into genetically dissimilar hosts without immunosuppression are generally defeated by the immune system of the host. Protective barrier coatings to isolate the transplant tissues from the host immune system have been attempted but coating materials were incompatible with the host system or were unsuitable.
This patent portfolio describes methods and techniques for coating biological materials such as tissues, cells and cell lines with a continuous, uniform, semi-permeable and bio-compatible coating. The novel coating is non-fibrogenic and does not cause immune reactions destructive to the transplant functionality. In addition, UC Davis researchers have developed an apparatus and method for coating these biological materials and other solid and semi-solid particles to form smooth and uniform size microcapsules.
The methods, techniques, and apparatus can be used in medical transplants such as islet cell transplantations.
The methods and apparatus provide an efficient process for:
- Fully operable non-fibrogenic coatings with perfected permeabilities to protect tissue cells from host immunological agents after transplantation
- Producing coatings with a high degree of control and reproducibility, at a rapid rate; therefore, enabling mass production of microcapsules
- Coating biological materials such as tissues, cells and cell lines and other semi-solid particles with a thin, uniform, continuous, and semi-permeable bio-compatible coating
- Forming a thin second coating on encapsulated cells or tissue while maintaining the diameter of the double or multiple-coated microcapsule
- Coating pancreatic islets, hepatic cells, calcitonin producing islets and other endocrine tissues and cells
- A safe, fast and non-invasive in situ removal of the coating and deactivation of the transplant by rejection of its core by the host immune system
|United States Of America||Issued Patent||5,531,997||07/02/1996||1989-160|
- Cochrum, Kent C.
1989-160-0, 1993-397-1, 1993-396-1, 1993-396-2, 1993-395-1, 1993-322-1, 1993-322-2, 1992-163-1, 1992-163-2, 1992-163-3, 1992-162-1, 1992-162-2, 1992-162-3, 1992-162-4
diabetes, type 1 diabetes, islet cell transplantation
PEOPLE WHO VIEWED THIS ALSO VIEWED THESE TECHNOLOGIES BY OTHER INVENTORS
- Saturated Fat Reduction In Non-Human Animals And Derivative Food Products
- Immunoassay for Polyunsaturated Fatty Acid Metabolites
- Real-time Characterization of Biological Materials
- Biomarkers for Ascertaining an Individual's Risk for Developing Alzheimer's Disease
- Real Time Adaptive External Immune System