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A Diagnostic And Extent Of Disease Multigene Assay For Thyroid Neoplasms
Brief description not available
Monocytes Associated With Immunotherapy Resistance
ATF3 as an Easily Measurable Injured Neuron-Specific Biomarker for Injuries of the Central Nervous System
Neuronal injury is the major pathology caused by CNS injuries like stroke or spinal cord injury. However, currently available biomarkers for CNS injuries are either not expressed in neurons at all, or are expressed constitutively in all neurons, regardless of whether the neurons are injured or not. ATF3 as a CNS injury biomarker is revolutionary because its baseline expression in CNS is very low, and it is rapidly induced only in CNS neurons shortly after CNS injuries like stroke or spinal cord injury. Of note, human serum ATF3 level can be easily measured by a commercially available ELISA kit.
Distinct Metabolic States Guide Maturation of Inflammatory and Tolerogenic Dendritic Cells
Scientists at UCSF and the Parker Institute of Cancer Immunotherapy have developed methods for characterizing dendritic cells as well as methods for identifying a dendritic cell as either an inflammatory or a tolerogenic dendritic cell. Their results provide important insights into previously obscured metabolic heterogeneity impacting immune profiles of immunogenic and tolerogenic dendritic cells (DC).
Strokewatch: Noninvasive Stroke Detection Using Electroencephalography (EEG)
METHODS FOR PREDICTING THE RESPONSE TO METHOTREXATE AND TREATING RHEUMATOID ARTHRITIS
Researchers at UCSF have developed methods of treating Rheumatoid arthritis and for predicting the response of patients to methotrexate.
AUTOANTIBODIES AS BIOMARKERS FOR AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
Researchers at UCSF and the Chan Zuckerberg Biohub have identified multiple common autoantibody targets in APS1 patients through proteome-wide programmable phage-display.
DETECTION ASSAY FOR SARS-COV-2 VIRUS
Researchers at UCSF and the Chan Zuckerberg Biohub have developed methods to detect SARS-CoV-2 virus.
BIOSENSOR DETECTION ASSAY FOR ANTI-SARS-COV-2 ANTIBODIES
Researchers at UCSF and the Chan Zuckerberg Biohub have developed a serological detection assay for anti-SARS-CoV-2 antibodies.
An Extracellular Vesicle Based Liquid Biopsy for Treatment Monitoring and Early Detection of Tumor Recurrence in Glioblastoma Patients
Designed Sensors Of Paralytic Shellfish Poisoning (PSP) Toxins
Blood Based T Cell Biomarker For Cancer Diagnosis And Treatment
In cancer care, specific characteristics of T cells can be used to measure a patient’s response to immunotherapy. Using single-cell RNA-sequencing coupled with TCR sequencing, scientists at UCSF and Harvard detected CD8+ T cell clones shared between blood and tumor in mice and melanoma patients, characterized these matching clones in blood and tumor, and identified potential biomarkers for their isolation in the blood. Their method reveals specific protein signatures (biomarkers) on the surface of T cells that can be therapeutically targeted to treat melanoma and other forms of cancer. It presents a very attractive alternative to obtaining invasive biopsy samples from the tumor, and can be done much more quickly.
Gene Expression Signatures of Intratumoral T cells as Biomarkers of Clinical Response and Increased Survival with Immune Checkpoint Inhibitor Therapy in Bladder Cancer
Non-Invasive Lesion-Specific Classification Of Nevus And Melanoma Using A MicroRNA Signature.
Gene expression risk score and algorithm for clinically aggressive meningioma identification and therapy guidance
Kelch Like Family Member 11 (Klhl11) Autoantibodies As Markers Of Seminoma Associated Paraneoplastic Encephalitis In Men
Researchers at UCSF and Chan Zuckerberg Biohub have discovered a novel biomarker for an autoimmune disease that affects patients with testicular cancer. The disease, known as “testicular cancer-associated paraneoplastic encephalitis,” can cause severe neurological symptoms. The symptoms include loss of limb control, eye movement, and in some cases, speech. The disease begins with testicular cancer, which in some cases causes the immune system to attack the brain. Affected patients are often misdiagnosed and appropriate treatment is delayed.
cBCI: Method and System for Diagnosing and Training Cognitive Fitness and Targeted Neural Network Function Underlying Cognitive Fitness in an Integrated Digital Approach
The inventors have created a brain computer interface (BCI) that serves as a diagnostic and training tool of cognitive abilities and neural network function.
NOVEL ANTIBODIES AGAINST EPHA2 FOR RESEARCH, DIAGNOSIS, AND TREATMENT OF CANCER
A novel monoclonal human antibody specific to the cell-surface exposed protein EphA2, which is over-expressed in many forms of cancer and is a validated therapeutic target.
T Cell Signature Predictive of Clinical Outcome with Immunomodulatory Treatment
Biomarkers to predict responsiveness to anti-CTLA-4 antibodies
“CT Mucus Score” - A New Scoring System that Quantifies Airway Mucus Impaction Using CT Scans
A novel method to measure airway mucus plugging using CT images from patients with asthma or chronic obstructive pulmonary disease (COPD) patients.
Novel Gut Microbiome-based Diagnostic and Therapeutic for Neonates at Risk of Childhood Atopy and Asthma
UCSF researchers have developed a novel gut microbiome-based diagnostic test and targeted treatment for early-life identification of atopy or asthma risk in children.
Novel Biomarker Panel for the Early Diagnosis of Lyme Disease
This diagnostic technology uses a panel of 20 biomarkers to diagnose Lyme disease with much higher sensitivity and accuracy than other currently existing methods. Lyme disease can be detected in peripheral blood samples from patients even at early hard-to-diagnose stages. These aspects of the invention make it indispensable for speeding up recovery and prevention of complications associated with this debilitating illness such as carditis, arthritis, neurological illness and even death.
Diagnostic for Precursor Lesions of Pancreatic Cancer
These highly specific biomarkers distinguish potentially malignant mucinous cysts from benign nonmucinous cysts in the pancreas to help diagnose precursor lesions of pancreatic ductal adenocarcinoma. The biomarkers can be detected through enzymatic assays with exceptional accuracy and sensitivity.
Novel Use of Chitinases for Treatment of Lung Inflammatory and Fibrotic Diseases
A novel approach for the treatment of lung inflammatory and fibrotic diseases by increased or repaired chitinase function in lung tissues
Biomarker of Dyskinesia to Customize Medication or Deep Brain Stimulation for Parkinson's Disease Patients
This invention has provided methods for detecting dyskinesia in Parkinson’s disease patients and provided a way to titrate current treatment to maximize benefits while minimizing side effects.