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INTEGRATED OPTICAL PEEL AWAY PLEUROSCOPIC TROCAR FOR USE IN PLEUROSCOPIC AND THORACIC PROCEDURES
Brief description not available
Strokewatch: Noninvasive Stroke Detection Using Electroencephalography (EEG)
Low-Intensity Pulsed Ultrasound (LIPUS) for Enhanced Testosterone Production and Treatment of Low Testosterone
Intraprocedural Grid Localization System for use in MRI-guided Breast Biopsies and Mammographic Localization Procedures
Minimal Erythema Dose Testing Device
UCSF researchers have developed a novel device to deliver multiple UV doses simultaneously to perform testing of the optimal safe and effective dose of UV for treatment of patients.
Neural Implant Platform for Direct and Large Surface-area Access to Brain
This invention is a neural implantation platform permitting large scale recording of brain activity, suitable for both animals and humans. The use of advanced silicone materials in the design allows for greater access to brain surface area than currently existing implantation platforms.
NOVEL BRAIN TECHNOLOGY FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS USING ELECTRICAL STIMULATIONS
This invention is a novel technology developed to treat a patient’s neurological and/or psychiatric conditions. It consists of a system of implantable devices and computational algorithms that not only has autonomous control in sensing and stimulation of electrical signals in the patient’s brain, but also enables interactions with the external environment, thereby enhancing training and learning.
Biomarker of Dyskinesia to Customize Medication or Deep Brain Stimulation for Parkinson's Disease Patients
This invention has provided methods for detecting dyskinesia in Parkinson’s disease patients and provided a way to titrate current treatment to maximize benefits while minimizing side effects.
Retractable Step Cannula For Brain Delivery Of Therapeutics
An adjustable step cannula to minimize therapeutic agent leakage and maximize on-target drug delivery. This new cannula design improves brain drug delivery over current fixed-length step cannulas.
Method for fabricating micron-scale stepped needles intended for the insertion of devices
This invention is a novel method for fabricating needles with stepped ends. The method uses a brazing technique to achieve a fine stepped needle meant for delivering probes into tissue. This method creates needles strong enough to be used in neural surgery, but thin enough (<15 um) to create a very minimal entry wound.
Omnidirectional MRI Catheter Resonator for Interventional Procedures
This invention describes an orientation-independent device that can create bright and highly localized signal enhancement during magnetic resonance imaging.
Redesigning the Hub Cap to Decrease Central Line Associated Blood Stream Infections
This is a novel mechanism for preventing infections in catheter hubs used in central lines.
Closed-Loop Stimulation Device for Enhancing Motor Function After Stroke
This novel brain stimulation device enhances motor function after stroke by modulating the neural network to be more excitable in a task-dependent manner.
System And Method For Rapid Automated Head Computed Tomography Analysis
This invention is a novel, automated method to rapidly detect and locate neurological emergencies such as acute intracranial hemorrhage on head computed tomography (CT) images using deep learning technology.
MR-guided Thermal Ablation Device for Pancreatic Tumors
An endoluminal ultrasound therapy device capable of operation under real-time MRI visualization for precision directed pancreatic tumor ablation.
A Real-time Intraoperative Fluorescent Imaging Device for Guided Surgical Excision of Microscopic Residual Tumors
This novel real-time imaging device can provide precise and rapid pathological imaging information of the tumor area by utilizing fluorescent or luminescent markers within the body to ensure complete surgical resection.
A Novel Method of Removing Stimulation Artifacts (SA) from Multichannel Electrical Recordings
This technology is a novel algorithm that can significantly remove stimulation artifacts (SA) from electrophysiological recording devices used for neuroscience research and/or clinical therapeutics.
Measurement Of Blood Flow Dynamics With X-Ray Computed Tomography: Dynamic Ct Angiography
This invention identifies a method to accurately measure flow dynamics, such as velocity and volume, from Computed Tomography scans of blood vessels in a patient.
Method for Reducing Nephrotoxic Effects Induced By Radiographic Contrast Material
A low frequency ultrasound-based method to minimize nephrotoxicity induced by radiographic contrast media (e.g. contrast agent or dye) when using diagnostic tests such as MRI, CT scans, and angiograms.
An Automated, Minimally-invasive Neural Interface System Providing the Means for Scalable Electrode Implantation
This invention provides an automated, high-throughput, minimally-invasive system to insert electrodes within the brain and other parts of the central nervous system (CNS). The system provides a means for inserting these electrodes within the brain with minimal to no disruption of the blood brain barrier (BBB). This feature is critical, as neural electrode failure is closely associated with inflammation resulting from the disruption of the BBB. Furthermore, this system will allow the implantation of electrodes within the CNS at a much higher density than current standards.
PRO- RESOLVING MEDIATORS AND DEVICES FOR THERAPEUTIC MODULATION OF BLOOD VESSEL HEALING
This invention consists of the use of a novel class(es) of anti-inflammatory and pro-resolving mediators derived from ω-3 polyunsaturated fatty acids, as well as devices designed to deliver these mediators directly to blood vessel for therapeutic modulation of blood vessel healing.
Nanophotonics-Based Implantable Iop-Sensor With Remote Optical Readout
This invention enables the remote automated monitoring of intraocular pressure in patients or animal models to inform glaucoma treatment and the development of new therapeutics for glaucoma.
NOVEL CARDIAC CATHETER
Cardiac catheterization, angioplasty, and related catheter-based interventions are known as the most significant discoveries made in cardiovascular medicine. Currently, >700,000 cardiac catheterizations and >600,000 percutaneous coronary interventions (PCI) are performed annually in the United States. Such techniques have evolved over the past century, providing researchers and physicians a better understanding of basic cardiovascular biology and have enabled accurate diagnoses, effective treatments of major cardiac diseases. Cardiac catheterization is a fundamental medical procedure used to diagnose and treat cardiovascular disease, including heart attack and stroke, the number one killer of men and women in the United States. Cardiac catheterization is a technically difficult procedure, requiring the skills of experienced medical physicians. Physicians are often faced with anatomical challenges, making it difficult to successfully execute cardiac catheterizations. In order to successfully complete the procedure, the equipment must traverse tortuous arteries and anatomical anomalies in order to reach the heart (e.g. tortuous subclavian arteries in trans-radial cardiac catheterization; tortuous iliac arteries in trans-femoral cardiac catheterization). Thus, there is a significant need for improved catheter design that overcomes such challenges without compromising medical benefit.
Modular Cell and Drug Delivery Cannula System
The use of cell transplantation in the brain shows great promise for the treatment of human neurological diseases, such as Parkinson's disease or stroke. Indeed, pre-clinical studies in animal models have shown significantly improved neurological function following cell grafting. However, in human trials the results have been considerably more variable. This has, in part, been attributed to concerns with poor cell distribution within the target area. A further issue that has arisen with the challenge of scaling up from animal models to humans is the increase in the number of transcortical penetrations required to deliver therapeutic agents. For surgical cell transplantation approaches, cell sedimentation and impaired graft viability are also concerns that need to be addressed to optimize the use of this therapeutic avenue.
Novel, less invasive biomarker to detect and monitor Parkinson's disease and other movement disorders
Parkinson’s disease (PD) and primary dystonia are common brain disorders that affect movement. Performing daily activities becomes increasing difficult and medication is insufficient for treatment of symptoms as severity increases. The best current technology for treatment of these disorders is deep brain stimulation (DBS) which uses stimulator electrodes inserted in the basal ganglia to alter electrical signaling. Determination of optimal stimulation is based on a “trial & error” approach and there is no accurate way to guide the therapy. Stimulation is performed as an “open loop”, meaning that there is no brain signal that can be used to monitor the effectiveness of therapy and control the stimulation automatically. Hence, programming of the stimulation requires several time consuming appointments before the optimal setting is determined; thus making it difficult to achieve immediate symptom relief. Identification of a novel method to guide DBS therapy for PD and dystonia is greatly needed.