University of California, Davis researchers have developed a computer algorithm that precisely measures the extent of brain atrophy on structural MRI images over successive time intervals.  The method achieves higher sensitivity and specificity than previous algorithms.  Due to the bias in images and in conventional algorithms, a penalty term reduces the algorithm sensitivity and localization, leading to an under-reporting of real change.  This algorithm restores sensitivity without losing specificity by also incorporating a priori tissue boundary information. (more...)

Researchers at the University of California, Davis have invented a device and methods for half-value layer (HVL) characterization in computed tomography (CT) to allow a medical physicist to measure the HVL of an X-ray system while the X-ray tube is rotating - that is, during its normal operation without the necessity to make the x-ray tube stationery. (more...)

Delivery of drugs by inhalation has numerous advantages. However, analyzing the performance of such drugs requires precise information on the drugs deposition pattern. Researchers at University of California, Davis have developed a method for imaging the exact deposition pattern of inhaled drugs and particles in tissue samples. (more...)

The 3-dimensional deposition pattern of drugs or particles in a subject’s airways strongly influences the impact of such drugs or particles on the subject.Scintigraphy is widely used to determine such deposition patterns.However, scintigraphy suffers from low spatial resolution and it requires exposing the subject to ionizing radiation. Researchers at University of California, Davis have developed a novel method for imaging the 3D distribution of particles in human airways that overcomes the above disadvantages of scintigraphy.The method has a significantly higher resolution than scintigraphy and does not expose the subject to ionizing radiation.The method also promises significant cost saving when compared to methods reliant on MRI. (more...)

Researchers at the University of California, Davis have developed an effective local therapeutic strategy with substantially reduced side effects using a combined treatment with increased and stable loading of doxorubicin (Dox) using a complex of Dox and copper (II). Cu-liposomes were loaded with Dox up to a maximum concentration of 0.6mg-drug/mg-lipid with 100% loading. UC Davis researchers have studied the efficacy of Cu-Dox liposomes and optimized the treatment strategy using the highly invasive and metastatic Met-1 tumor, a syngeneic model of human breast carcinoma. All animals receiving the combined therapy survived throughout the 28 day course treatment and did not show any side effects throughout the 28 day of treatment. A significant tumor regression was accomplished on combining Cu-Dox liposomes with another drug and tumor insonation. (more...)

New materials and methods that enable the simple inclusion of 18F into cancer-targeting peptides that can be used as radiolabels for PET imaging (more...)

Detect breast cancer earlier using an innovative new computed tomography (CT) imaging system. (more...)

Construction of Multivalent Antibody scFv Through Cu(I) Catalyzed 1,3-Dipolar Cycloaddition (more...)

Aβ-binding Small Molecules for Alzheimer's Disease Treatment and Imaging (more...)