Researchers at the University of California, Davis have developed ibogaine-related compounds that promote neural plasticity and treat neuropsychiatric and neurological disorders.

Researchers at the University of California, Davis have developed a class of compounds intended for the treatment of neurodegenerative diseases such as Alzheimer's by inhibiting DYRK1A kinase and modulating 5-HT2Rs.

Brief description not available

Brief description not available

Researchers at the University of California, Davis have developed a protein-based composition and method that protects bioactive bacteria from thermal and osmotic stress during dehydration to maintain viability and shelf life.

Researchers at the University of California, Davis have developed a method that uses phenolic-rich agro-industrial residues to protect and stabilize beneficial microbes for improved shelf life and bioactivity.

Reactive oxygen species (ROS), including hydrogen peroxide and peroxynitrite, play dual roles as essential signaling molecules and high-stress markers of cellular damage. However, imaging these volatile species in live biological systems is often hindered by diffusion and poor signal localization. Researchers at UC Berkeley have developed a "tandem" activity-based sensing and labeling strategy that overcomes these challenges. This technology utilizes selective chemical probes that, upon reacting with a specific ROS, undergo a transformation that simultaneously triggers a fluorescent signal and anchors the probe to nearby cellular proteins. By "trapping" the signal at the site of its production, this dual-action mechanism allows for high-resolution, localized imaging of oxidative stress and signaling events within complex cellular environments.

Brief description not available

Researchers at the University of California, Davis have developed advanced epigenetic methods and systems that detect and assess developmental risks in embryos caused by maternal stress prior to conception.

Researchers at the University of California, Davis have developed a unique non-sacrificial synthetic peptide substrate designed to inhibit plasmin activity and prevent tumor progression and ascites formation in cancers characterized by elevated plasmin levels.

Researchers at the University of California, Davis have developed a method for creating annealed microgel scaffolds using polyethylene glycol-vinyl sulfone, offering improved efficiency and shelf life.

Researchers at the University of California, Davis have developed a method and composition that direct the growth of long, coronally oriented blood vessels in tissue grafts to improve vascularization and clinical transplant outcomes.

The success of gene therapy relies heavily on the ability of delivery vehicles to reach specific cells without being intercepted by the immune system or accumulating in non-target organs. UC Berkeley researchers have developed engineered capsids for recombinant adeno-associated virus that are specifically optimized to target Schwann cells, which are the essential support cells of the peripheral nervous system. While naturally occurring varieties like adeno-associated virus 1 and adeno-associated virus 2 often struggle to infect these cells efficiently or are diverted to the liver, these new variant capsids show significantly increased infectivity in Schwann cells. Furthermore, they are designed to be more resistant to the neutralizing antibodies commonly found in humans, which can often render traditional viral treatments ineffective. This breakthrough enhances both the manufacturing potential and the safety profile of genetic treatments for peripheral nerve disorders.

Brief description not available

Researchers at the University of California, Davis, have created a technology that uses engineered polynucleotides to deliver both an antigen and an enzyme that breaks down amino acids. This approach is designed to boost long-lasting memory T-cell responses, providing stronger protection against infectious diseases and cancer.

Brief description not available

Brief description not available

Brief description not available

Researchers at the University of California, Davis have developed a machine learning system for accurately separating fetal signals from mixed maternal-fetal photoplethysmography signals acquired non-invasively to enable fetal physiological parameter monitoring.

Autoimmune disorders such as ankylosing spondylitis are heavily linked to specific genetic human tissue types, particularly variations of the human leukocyte antigen B27. Traditional treatments for these debilitating conditions often rely on broad immunosuppression, which weakens a patient's entire immune defense and increases the risk of infections. To provide a more precise solution, UC Berkeley researchers have developed small-molecule ligands that selectively target and block a specific disease-associated variation of this allele, known as human leukocyte antigen B27:05. The therapeutic compounds feature a distinct three-part molecular architecture that includes a targeted binding group designed to fit securely into a specific molecular pocket, a flexible chemical linker, and a reactive group that forms a stable bond with a neighboring cysteine amino acid residue. By turning off only the specific genetic driver responsible for the autoimmune reaction, this technology opens the door to highly targeted therapies that treat the root cause of the disease while leaving the rest of the immune system fully functional.

Brief description not available

RNA-guided DNA targeting systems have fundamentally changed the landscape of genomic research and therapeutic development, yet the large size of traditional CRISPR tools creates a "delivery bottleneck" for therapeutic vectors. While the TIGR-Tas protein family offers a compact alternative for streamlined delivery, naturally occurring TasR proteins often lack the cleavage efficiency required for complex biological environments. UC Berkeley researchers have overcome this by engineering high-performance variants of ParTasR. This system is approximately one-quarter the size of Cas9. The engineered proteins demonstrate significantly higher on-target cleavage activity than wild-type sequences, offering a potent and hyper-compact alternative for the next generation of in vivo genome editing. 

Researchers at the University of California, Davis have developed a novel nanobody specific for WISP2 that restores skeletal stem cell function to treat bone loss and promote bone growth in age-related bone diseases.

Brief description not available

An advanced wearable bio-electronic device for non-invasive abnormality prediction, early diagnostics, and disease prevention.